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• W2024285800 abstract "The characteristics of the inwardly rectifying K+ current activated by a μ-type opioid agonist, d-Ala2,N-MePhe4,Gly5-ol-enkephalin (DAMGO), were examined in the acutely dissociated rat periaqueductal gray neurons using the nystatin-perforated and the conventional whole-cell recording modes under voltage-clamp conditions. DAMGO activated inward currents in a concentration- and voltage-dependent manner. The DAMGO-induced current was an inwardly rectifying K+ current (IDAMGO) which was sensitive to K+ channel blockers, quinine and Ba2+ but insensitive to Cs+ and tetraethylammonium. In the conventional whole-cell clamp mode, guanosine 5′-O-(2-thiodiphosphate) trilithium salt (GDPβs, 0.4 mM) inhibited the amplitude of IDAMGO to 28% of that of the initial current. After the intracellular perfusion with guanosine 5′-[loc]O-(3-thiotriphosphate) tetralithium salt (GTPγs, 0.4 mM) for 1 min, the first application of DAMGO irreversibly activated IDAMGO. By the extracellular application of N-ethylmaleimide at a concentration of 50 μM for 2 min, IDAMGO was completely abolished. When a conventional whole-cell patch was made with a patch-pipette containing 1 μg/ml of pertussis toxin together with 1 mM of β-nicotinamide adenine dinucleotide, IDAMGO gradually declined to about 41% of its initial amplitude. The extracellular application of second messenger modulators including protein kinase inhibitor (staurosporin), protein kinase A activators (forskolin, 3-isobutyl-1-methyl-xanthine and dibutyryladenosine 3′5′-cyclic monophosphate) and protein kinase C activators (phorbol-12-myristate-13-acetate and 1-oleoyl-2-acetyl-sn-glycerol) had no effect on IDAMGO. These results suggest that (i) DAMGO-activated inwardly rectifying K+ current is mediated by pertussis toxin-sensitive guanine nucleotide binding proteins (G-proteins); (ii) the types of G protein involved in IDAMGO are Gi and/or Go; and (iii) the G-proteins exert their roles in IDAMGO without any mediation of the second messenger systems." @default.
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• W2024285800 date "1999-02-01" @default.
• W2024285800 modified "2023-10-17" @default.
• W2024285800 title "μ-opioid agonist-induced activation of G-protein-coupled inwardly rectifying potassium current in rat periaqueductal gray neurons" @default.
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• W2024285800 doi "https://doi.org/10.1016/s0306-4522(98)00409-6" @default.
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