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• W2024286178 abstract "Recent studies have demonstrated that MICA (major histocompatibility complex class I chain-related genes) on the short arm of the chromosome 6 are associated with susceptibility to various autoimmune diseases in Caucasians. The aim of our study was to investigate the role of MICA in type 1 diabetes susceptibility independent of the HLA DR-DQ polymorphism in genetically distinct Koreans.A total of 119 patients selected from Korean Seoul type 1 diabetes registry and 134 nondiabetic unrelated control subjects were typed for exon 5 polymorphism of MICA in addition to HLA DR-DQ typing. A total of 52 simplex families of type 1 diabetes were also studied.The MICA microsatellite allele consisting of six repetitions of GCT/AGC (A6) was present at a significantly lower frequency in the diabetic patient group (Pc < 0.01; Pc = P value after Bonferroni correction) than in the control population. The MICA microsatellite allele consisting of four repetitions (A4) was present at a higher frequency in diabetic patients (P < 0.05). This deviated distribution was not changed even after controlling for the HLA DRB1-DQB1 haplotype. Transmission/disequilibrium test revealed significant deviation of transmission for alleles at the A6 polymorphism within the MICA gene (P < 0.05).We could assess that the MICA gene might be associated with type 1 diabetes transracially independent of the HLA gene." @default.
• W2024286178 created "2016-06-24" @default.
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• W2024286178 date "2001-01-01" @default.
• W2024286178 modified "2023-10-10" @default.
• W2024286178 title "MICA Polymorphism Is Associated With Type 1 Diabetes in the Korean Population" @default.
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• W2024286178 doi "https://doi.org/10.2337/diacare.24.1.33" @default.
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