Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024288840> ?p ?o ?g. }
- W2024288840 endingPage "1392" @default.
- W2024288840 startingPage "1385" @default.
- W2024288840 abstract "Neurotrophic factors have been used for the treatment of several neurodegenerative diseases. However, their use is limited by their inability to cross the blood-brain barrier, their short half life and their side effects. SR 57746A is a new orally active compound that exhibits in vivo and in vitro neurotrophic effects in several experimental models. We show here that SR 57746A (1 μM) increases the phenotypic survival of embryonic purified mouse motoneurons in vitro to the same extent as brain-derived neurotrophic factor (100 ng ml−1), and increases the outgrowth and number of their neurites. It acts in a dose-dependent manner up to 1 μM which is the optimal concentration. Above this concentration, its neurotrophic effect decreases. Genistein (10 μM), a protein tyrosine kinase inhibitor, also increases the phenotypic survival and differentiation of mouse motoneurons. It does not act in a synergistic or additive manner with SR 57746A. However, at concentrations equal or superior to 25 μM, it decreases the survival of motoneurons. This suggests that the neurotrophic effect of genistein is due to a favourable alteration of equilibrium between phosphorylated and dephosphorylated states of proteins involved in survival and differentiation of motoneurons. Like genistein, SR 57746A should be used at a critical concentration (1 μM) to exert its optimal effects. Since SR 57746A does not act synergistically with genistein, it is likely that its mechanism of action involves a pathway similar to that affected by this tyrosine kinase inhibitor. At the present time, SR 57746A is the only orally active compound and the only synthetic compound shown to be active on motoneurons in vitro. It should thus be considered as a good candidate for the treatment of motoneuron diseases. British Journal of Pharmacology (1999) 128, 1385–1392; doi:10.1038/sj.bjp.0702910" @default.
- W2024288840 created "2016-06-24" @default.
- W2024288840 creator A5013423658 @default.
- W2024288840 creator A5060617685 @default.
- W2024288840 creator A5065609435 @default.
- W2024288840 creator A5082726314 @default.
- W2024288840 date "1999-12-01" @default.
- W2024288840 modified "2023-09-30" @default.
- W2024288840 title "Effect of the nonpeptide neurotrophic compound SR 57746A on the phenotypic survival of purified mouse motoneurons" @default.
- W2024288840 cites W1521573047 @default.
- W2024288840 cites W1571410849 @default.
- W2024288840 cites W1573593065 @default.
- W2024288840 cites W1656644300 @default.
- W2024288840 cites W1664741673 @default.
- W2024288840 cites W174883411 @default.
- W2024288840 cites W1896539662 @default.
- W2024288840 cites W1967898959 @default.
- W2024288840 cites W1980084712 @default.
- W2024288840 cites W1996932508 @default.
- W2024288840 cites W1999972660 @default.
- W2024288840 cites W2008291157 @default.
- W2024288840 cites W2011311134 @default.
- W2024288840 cites W2011856091 @default.
- W2024288840 cites W2012207465 @default.
- W2024288840 cites W2019687443 @default.
- W2024288840 cites W2019825241 @default.
- W2024288840 cites W2020333978 @default.
- W2024288840 cites W2031103586 @default.
- W2024288840 cites W2032152929 @default.
- W2024288840 cites W2032475286 @default.
- W2024288840 cites W2034108437 @default.
- W2024288840 cites W2040358411 @default.
- W2024288840 cites W2045644801 @default.
- W2024288840 cites W2048646985 @default.
- W2024288840 cites W2052521712 @default.
- W2024288840 cites W2054354916 @default.
- W2024288840 cites W2072626617 @default.
- W2024288840 cites W2076152511 @default.
- W2024288840 cites W2077518324 @default.
- W2024288840 cites W2079687595 @default.
- W2024288840 cites W2082693827 @default.
- W2024288840 cites W2090373637 @default.
- W2024288840 cites W2090982721 @default.
- W2024288840 cites W2095454466 @default.
- W2024288840 cites W2098719212 @default.
- W2024288840 cites W2149533590 @default.
- W2024288840 cites W4313333755 @default.
- W2024288840 doi "https://doi.org/10.1038/sj.bjp.0702910" @default.
- W2024288840 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1571767" @default.
- W2024288840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10602316" @default.
- W2024288840 hasPublicationYear "1999" @default.
- W2024288840 type Work @default.
- W2024288840 sameAs 2024288840 @default.
- W2024288840 citedByCount "28" @default.
- W2024288840 countsByYear W20242888402012 @default.
- W2024288840 countsByYear W20242888402014 @default.
- W2024288840 countsByYear W20242888402017 @default.
- W2024288840 countsByYear W20242888402018 @default.
- W2024288840 countsByYear W20242888402021 @default.
- W2024288840 countsByYear W20242888402023 @default.
- W2024288840 crossrefType "journal-article" @default.
- W2024288840 hasAuthorship W2024288840A5013423658 @default.
- W2024288840 hasAuthorship W2024288840A5060617685 @default.
- W2024288840 hasAuthorship W2024288840A5065609435 @default.
- W2024288840 hasAuthorship W2024288840A5082726314 @default.
- W2024288840 hasBestOaLocation W20242888402 @default.
- W2024288840 hasConcept C113246987 @default.
- W2024288840 hasConcept C11960822 @default.
- W2024288840 hasConcept C134018914 @default.
- W2024288840 hasConcept C160539049 @default.
- W2024288840 hasConcept C170493617 @default.
- W2024288840 hasConcept C185856081 @default.
- W2024288840 hasConcept C202751555 @default.
- W2024288840 hasConcept C2778298627 @default.
- W2024288840 hasConcept C2778790584 @default.
- W2024288840 hasConcept C42362537 @default.
- W2024288840 hasConcept C55493867 @default.
- W2024288840 hasConcept C62478195 @default.
- W2024288840 hasConcept C86803240 @default.
- W2024288840 hasConcept C92020748 @default.
- W2024288840 hasConcept C95444343 @default.
- W2024288840 hasConcept C97029542 @default.
- W2024288840 hasConcept C98274493 @default.
- W2024288840 hasConceptScore W2024288840C113246987 @default.
- W2024288840 hasConceptScore W2024288840C11960822 @default.
- W2024288840 hasConceptScore W2024288840C134018914 @default.
- W2024288840 hasConceptScore W2024288840C160539049 @default.
- W2024288840 hasConceptScore W2024288840C170493617 @default.
- W2024288840 hasConceptScore W2024288840C185856081 @default.
- W2024288840 hasConceptScore W2024288840C202751555 @default.
- W2024288840 hasConceptScore W2024288840C2778298627 @default.
- W2024288840 hasConceptScore W2024288840C2778790584 @default.
- W2024288840 hasConceptScore W2024288840C42362537 @default.
- W2024288840 hasConceptScore W2024288840C55493867 @default.
- W2024288840 hasConceptScore W2024288840C62478195 @default.
- W2024288840 hasConceptScore W2024288840C86803240 @default.
- W2024288840 hasConceptScore W2024288840C92020748 @default.
- W2024288840 hasConceptScore W2024288840C95444343 @default.