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• W2024289763 abstract "Abstract N -Nitrosomethylurea was used to induce mutational events at the dumpy locus of Drosophila melanogaster . The results show that a 0.1% concentration of the agent induces a mutation frequency of 1.8%, which is comparable to that found for ICR-170 or ethyl methanesulfonate. The mutant spectrum of F 1 dumpy mutants induced by N -nitrosomethylurea does not differ appreciably from the spectrum obtained following the application of ICR-170. It does differ from the spectrum of mutants for X-ray mutagenesis, which induces a class of variegated dumpy mutants not found for ICR-170 or N -nitrosomethylurea. The percentage of mutant somatic tissue within each induced dumpy mutant was calculated by the identification and isolation of mosaic (fractional) mutants and complete (whole body) mutants. Like ICR-170 mutagenesis, phenotypically mosaic mutants predominate in the progency counts produced by postmeiotic sperm. In contrast, phenotypically complete mutants predominate in progeny counts produced by postmeiotic sperm following X-ray mutagenesis. Approx. 25% of the fertile F 1 dumpy mutants transmitted a dumpy phenotype to the F 2 generation. This is similar to the 25% transmittance obtained for ICR-170 but it is considerably less than the 72% transmittance established for X-ray induced mutants. In addition, the transmission test showed that the fertile F 1 mutants, irrespective of their somatic mutant expression, may possess any one of three types of gonads; completely normal, completely mutant, or fractionally mutant. A translocation test, employed to detect chromosomal breakage showed a 0.5% frequency of translocations between the second and the third chromosomes. This low frequency of breakage, in conjunction with the absence of the variegated dumpy class, suggests that the mode of action of this agent is based on a molecular alteration of the genetic material within the dumpy locus rather than on breakage events involving the addition, rearrangement, or deletion of large pieces of the chromosome bearing the dumpy locus. N -Nitrosomethylurea induces a high incidence of sterility in the premeiotic progeny broods. The ability of N -nitrosomethylurea to react chemically with the DNA polymer by means of the diazonium radical and the effect that this would have on meiosis is proposed as the major mechanism leading to male sterility. The induced sterility cannot be attributed to the small amount of breakage induced by the mutagen." @default.
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• W2024289763 date "1968-03-01" @default.
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• W2024289763 title "The mutagenic effect of N-nitrosomethylurea on the dumpy locus in Drosophila melanogaster" @default.
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• W2024289763 doi "https://doi.org/10.1016/0027-5107(68)90024-9" @default.
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