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• W2024293755 abstract "Background The aim of this study was to investigate the left ventricular (LV) remodeling and function in 24 asymptomatic young adults affected by β-thalassemia intermedia (TI), in order to compare the obtained data with that of 80 patients affected by β-thalassemia major (TM) and 65 healthy subjects. Methods LV volumes and shapes, mass index, mass/volume ratio, systolic and diastolic function, stroke volume, and cardiac index were determined by two-dimensional and M-mode echocardiography. Results In the TM and TI groups, LV volumes, diastolic and systolic shapes were significantly different from the control subjects, but the ejection fraction was slightly reduced only in the TM group. The TI group had larger LV volumes than did the TM group (mean [± SD] end-diastolic volume index, 99.4 ± 21.9 vs 82.7 ± 21.5 mL/m2, respectively [p < 0.005]; mean end-systolic volume index, 42.8 ± 12.2 vs 36.1 ± 12.9 mL/m2, respectively[p < 0.05]). Both groups showed an increase of the LV mass index, but the mass/volume ratio did not differ from the control subjects. The systolic volume index and the cardiac index were increased in both groups, but the increase was more pronounced in the TI group. Fractional shortening (FS) and the mean velocity of circumferential shortening (mVCFc) were decreased in the TM group (FS, 33.6 ± 5.5% vs 36.9 ± 4.1, respectively [p < 0.001]; mVCFc, 1.06 ± 0.18 vs 1.17 ± 0.12 circumference per second, respectively [p < 0.0001]). The LV contractile state was depressed only in the TM group, and the preload index was normal in both. LV filling showed an increase in the total flow velocity integral due to increases in the peak E wave (E) and peak A wave (A) velocities and integrals, with an increase of the E/A ratio in the TM group and a slight decrease in the TI group. The isovolumic relaxation time was prolonged in both groups. There was no major derangement in the pulmonary venous flow. Conclusions Asymptomatic young adults with TI show significant increases in LV volumes, LV mass, and cardiac index that are more pronounced than those in TM patients. LV systolic function is preserved in the TI group but is slightly depressed in the TM group due to the increase of afterload and to reduced contractility. The hemodynamic and hematologic factors involved in the etiopathogenesis of these findings are discussed, such as the treatment strategy. The aim of this study was to investigate the left ventricular (LV) remodeling and function in 24 asymptomatic young adults affected by β-thalassemia intermedia (TI), in order to compare the obtained data with that of 80 patients affected by β-thalassemia major (TM) and 65 healthy subjects. LV volumes and shapes, mass index, mass/volume ratio, systolic and diastolic function, stroke volume, and cardiac index were determined by two-dimensional and M-mode echocardiography. In the TM and TI groups, LV volumes, diastolic and systolic shapes were significantly different from the control subjects, but the ejection fraction was slightly reduced only in the TM group. The TI group had larger LV volumes than did the TM group (mean [± SD] end-diastolic volume index, 99.4 ± 21.9 vs 82.7 ± 21.5 mL/m2, respectively [p < 0.005]; mean end-systolic volume index, 42.8 ± 12.2 vs 36.1 ± 12.9 mL/m2, respectively[p < 0.05]). Both groups showed an increase of the LV mass index, but the mass/volume ratio did not differ from the control subjects. The systolic volume index and the cardiac index were increased in both groups, but the increase was more pronounced in the TI group. Fractional shortening (FS) and the mean velocity of circumferential shortening (mVCFc) were decreased in the TM group (FS, 33.6 ± 5.5% vs 36.9 ± 4.1, respectively [p < 0.001]; mVCFc, 1.06 ± 0.18 vs 1.17 ± 0.12 circumference per second, respectively [p < 0.0001]). The LV contractile state was depressed only in the TM group, and the preload index was normal in both. LV filling showed an increase in the total flow velocity integral due to increases in the peak E wave (E) and peak A wave (A) velocities and integrals, with an increase of the E/A ratio in the TM group and a slight decrease in the TI group. The isovolumic relaxation time was prolonged in both groups. There was no major derangement in the pulmonary venous flow. Asymptomatic young adults with TI show significant increases in LV volumes, LV mass, and cardiac index that are more pronounced than those in TM patients. LV systolic function is preserved in the TI group but is slightly depressed in the TM group due to the increase of afterload and to reduced contractility. The hemodynamic and hematologic factors involved in the etiopathogenesis of these findings are discussed, such as the treatment strategy." @default.
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• W2024293755 date "2002-02-01" @default.
• W2024293755 modified "2023-09-26" @default.
• W2024293755 title "Left Ventricular Remodeling, Systolic Function, and Diastolic Function in Young Adults With β-Thalassemia Intermedia" @default.
• W2024293755 cites W1938248030 @default.
• W2024293755 cites W1974440970 @default.
• W2024293755 cites W1975208970 @default.
• W2024293755 cites W1978493335 @default.
• W2024293755 cites W1986409524 @default.
• W2024293755 cites W1991609206 @default.
• W2024293755 cites W1998902832 @default.
• W2024293755 cites W2001259809 @default.
• W2024293755 cites W2007695755 @default.
• W2024293755 cites W2009243683 @default.
• W2024293755 cites W2010564928 @default.
• W2024293755 cites W2016919821 @default.
• W2024293755 cites W2021414189 @default.
• W2024293755 cites W2024335757 @default.
• W2024293755 cites W2026386089 @default.
• W2024293755 cites W2027084618 @default.
• W2024293755 cites W2037097663 @default.
• W2024293755 cites W2037749245 @default.
• W2024293755 cites W2038877005 @default.
• W2024293755 cites W2039956583 @default.
• W2024293755 cites W2042156881 @default.
• W2024293755 cites W2048204220 @default.
• W2024293755 cites W2050818720 @default.
• W2024293755 cites W2061350957 @default.
• W2024293755 cites W2067852287 @default.
• W2024293755 cites W2072001761 @default.
• W2024293755 cites W2075583680 @default.
• W2024293755 cites W2084404360 @default.
• W2024293755 cites W2090387813 @default.
• W2024293755 cites W2091680942 @default.
• W2024293755 cites W2093998596 @default.
• W2024293755 cites W2096073058 @default.
• W2024293755 cites W2099727192 @default.
• W2024293755 cites W2104475665 @default.
• W2024293755 cites W2107186577 @default.
• W2024293755 cites W2109004475 @default.
• W2024293755 cites W2118420936 @default.
• W2024293755 cites W2144867657 @default.
• W2024293755 cites W2150816115 @default.
• W2024293755 cites W2313234626 @default.
• W2024293755 cites W2317072972 @default.
• W2024293755 cites W2337471525 @default.
• W2024293755 cites W2990123797 @default.
• W2024293755 cites W7483294 @default.
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• W2024293755 doi "https://doi.org/10.1378/chest.121.2.506" @default.
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