FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024294172> ?p ?o ?g. }

• W2024294172 endingPage "160" @default.
• W2024294172 startingPage "149" @default.
• W2024294172 abstract "<i>Background:</i> Leptin is a pleiotropic hormone that is involved in the regulation of food intake and body weight. Recent findings demonstrated that leptin receptors are present in the pancreas but the involvement of leptin in pancreatitis remains unknown. The aim of the present study was: (1) to assess plasma leptin levels in rats with caerulein-induced pancreatitis (CIP) and humans with acute pancreatitis; and (2) to determine the effects of exogenous leptin on the course of acute CIP in rats <i>Methods</i>: CIP was produced in Wistar rats by s.c. infusion of 5 µg of caerulein for 5 h. Plasma leptin was measured by specific RIA and leptin expression in the pancreas was determined at the transcriptional and protein levels. In addition, the effects of exogenous leptin at the doses of 1 or 10 µg/kg i.p. on the course of CIP and the plasma levels and mRNA expression in pancreas of cytokines TNFα and IL-4 were studied. Furthermore, pancreatic cNOS and iNOS expression at mRNA level were measured in rats with CIP and pretreated with leptin. Parallel to these studies, the plasma levels of leptin were measured in 15 patients with acute edematous pancreatitis and in 30 healthy controls of comparable age and body mass index. <i>Results</i>: In rats, plasma leptin rose significantly from the median of 0.14 (0.03–0.3 ng/ml) in the control group to 0.56 (0.2–3.2 ng/ml) in rats with CIP. The CIP was associated with an upregulation of mRNA and protein for leptin in the pancreas. The administration of exogenous leptin significantly reduced the weight of pancreas, histological manifestations of pancreatitis, plasma TNFα and mRNA expression for iNOS in the pancreatic tissue. The assessment of leptin plasma level in humans demonstrated significantly higher median values of plasma leptin in patients with acute pancreatitis [7.5 (4.3–18.4 ng/ml)] than in healthy controls [2.1 (1.0–11.8 ng/ml)]. <i>Conclusions</i>: (1) Acute pancreatitis in rats and in humans is associated with a marked increase in the plasma level of leptin. (2) The transcriptional upregulation of leptin in the pancreas after induction of pancreatitis indicates that the inflammed pancreas could be the source of local production of leptin. (3) Exogenous leptin protects the pancreas against development of acute CIP in rats and one possible mechanism of action of leptin might be attributed to the activation of nitric oxide pathway." @default.
• W2024294172 created "2016-06-24" @default.
• W2024294172 creator A5015501774 @default.
• W2024294172 creator A5053500142 @default.
• W2024294172 creator A5063091785 @default.
• W2024294172 creator A5064803768 @default.
• W2024294172 creator A5067941526 @default.
• W2024294172 creator A5075403834 @default.
• W2024294172 creator A5087690868 @default.
• W2024294172 date "2002-01-01" @default.
• W2024294172 modified "2023-10-12" @default.
• W2024294172 title "Leptin Modulates the Inflammatory Response in Acute Pancreatitis" @default.
• W2024294172 cites W1590709474 @default.
• W2024294172 cites W1968173739 @default.
• W2024294172 cites W1990034749 @default.
• W2024294172 cites W1997634690 @default.
• W2024294172 cites W2019137326 @default.
• W2024294172 cites W2060124672 @default.
• W2024294172 cites W2062683793 @default.
• W2024294172 cites W2091556962 @default.
• W2024294172 cites W2127632638 @default.
• W2024294172 cites W2134812217 @default.
• W2024294172 cites W2138579618 @default.
• W2024294172 cites W2164384489 @default.
• W2024294172 cites W4240860350 @default.
• W2024294172 doi "https://doi.org/10.1159/000064935" @default.
• W2024294172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12138320" @default.
• W2024294172 hasPublicationYear "2002" @default.
• W2024294172 type Work @default.
• W2024294172 sameAs 2024294172 @default.
• W2024294172 citedByCount "56" @default.
• W2024294172 countsByYear W20242941722012 @default.
• W2024294172 countsByYear W20242941722014 @default.
• W2024294172 countsByYear W20242941722015 @default.
• W2024294172 countsByYear W20242941722016 @default.
• W2024294172 countsByYear W20242941722017 @default.
• W2024294172 countsByYear W20242941722018 @default.
• W2024294172 countsByYear W20242941722019 @default.
• W2024294172 countsByYear W20242941722020 @default.
• W2024294172 countsByYear W20242941722021 @default.
• W2024294172 crossrefType "journal-article" @default.
• W2024294172 hasAuthorship W2024294172A5015501774 @default.
• W2024294172 hasAuthorship W2024294172A5053500142 @default.
• W2024294172 hasAuthorship W2024294172A5063091785 @default.
• W2024294172 hasAuthorship W2024294172A5064803768 @default.
• W2024294172 hasAuthorship W2024294172A5067941526 @default.
• W2024294172 hasAuthorship W2024294172A5075403834 @default.
• W2024294172 hasAuthorship W2024294172A5087690868 @default.
• W2024294172 hasConcept C126322002 @default.
• W2024294172 hasConcept C134018914 @default.
• W2024294172 hasConcept C14372207 @default.
• W2024294172 hasConcept C2775967933 @default.
• W2024294172 hasConcept C2776670229 @default.
• W2024294172 hasConcept C2778764654 @default.
• W2024294172 hasConcept C2780613262 @default.
• W2024294172 hasConcept C511355011 @default.
• W2024294172 hasConcept C71315377 @default.
• W2024294172 hasConcept C71924100 @default.
• W2024294172 hasConceptScore W2024294172C126322002 @default.
• W2024294172 hasConceptScore W2024294172C134018914 @default.
• W2024294172 hasConceptScore W2024294172C14372207 @default.
• W2024294172 hasConceptScore W2024294172C2775967933 @default.
• W2024294172 hasConceptScore W2024294172C2776670229 @default.
• W2024294172 hasConceptScore W2024294172C2778764654 @default.
• W2024294172 hasConceptScore W2024294172C2780613262 @default.
• W2024294172 hasConceptScore W2024294172C511355011 @default.
• W2024294172 hasConceptScore W2024294172C71315377 @default.
• W2024294172 hasConceptScore W2024294172C71924100 @default.
• W2024294172 hasIssue "3" @default.
• W2024294172 hasLocation W20242941721 @default.
• W2024294172 hasLocation W20242941722 @default.
• W2024294172 hasOpenAccess W2024294172 @default.
• W2024294172 hasPrimaryLocation W20242941721 @default.
• W2024294172 hasRelatedWork W1976946227 @default.
• W2024294172 hasRelatedWork W1986171586 @default.
• W2024294172 hasRelatedWork W1994686423 @default.
• W2024294172 hasRelatedWork W2022716990 @default.
• W2024294172 hasRelatedWork W2049266444 @default.
• W2024294172 hasRelatedWork W2100782952 @default.
• W2024294172 hasRelatedWork W2138466941 @default.
• W2024294172 hasRelatedWork W2148844770 @default.
• W2024294172 hasRelatedWork W2416108475 @default.
• W2024294172 hasRelatedWork W2772070342 @default.
• W2024294172 hasVolume "65" @default.
• W2024294172 isParatext "false" @default.
• W2024294172 isRetracted "false" @default.
• W2024294172 magId "2024294172" @default.
• W2024294172 workType "article" @default.