Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024295268> ?p ?o ?g. }
- W2024295268 endingPage "1185" @default.
- W2024295268 startingPage "1175" @default.
- W2024295268 abstract "We studied the role of several serotonin (5-HT) and histamine receptors in the regulation of human umbilical artery (HUA) contractility. Among the 5-HT agonists used, only the 5-HT 2A and 5HT1B/D agonists contracts HUA. The 5-HT-induced contractions were fully inhibited by ketanserin (5-HT2A antagonist). The 5-HT 7-activation also relaxes and increases intracellular cyclic adenosine monophosphate (cAMP). Among the histamine receptor agonists, only betahistine (H1 agonist) induced significant contractile effect. Histamine-induced contraction was partially relaxed by pyrilamine (H1 antagonist). Betahistine-induced contraction was partially blocked by dimaprit (H 2 agonist) and by the H3 agonist when a low concentration of forskolin is present. Both, H2 and H3 agonists increased the cAMP intracellular levels in HUA smooth muscle. These findings show that in HUA, 5-HT2A- and 5-HT1B/1D-activation lead to vasoconstriction and 5-HT7-activation induces vasorelaxation. Concerning histamine receptors, H1-activation induces contraction and H2- and H3-activation lead to vasorelaxation." @default.
- W2024295268 created "2016-06-24" @default.
- W2024295268 creator A5030750604 @default.
- W2024295268 creator A5066592719 @default.
- W2024295268 creator A5072831168 @default.
- W2024295268 creator A5074018044 @default.
- W2024295268 date "2009-12-01" @default.
- W2024295268 modified "2023-09-27" @default.
- W2024295268 title "Regulation of Human Umbilical Artery Contractility By Different Serotonin and Histamine Receptors" @default.
- W2024295268 cites W1558123896 @default.
- W2024295268 cites W1964665214 @default.
- W2024295268 cites W1969220958 @default.
- W2024295268 cites W1971384513 @default.
- W2024295268 cites W1974488044 @default.
- W2024295268 cites W1975448919 @default.
- W2024295268 cites W1975848276 @default.
- W2024295268 cites W1980633979 @default.
- W2024295268 cites W1982866036 @default.
- W2024295268 cites W1993974089 @default.
- W2024295268 cites W1995838863 @default.
- W2024295268 cites W1996944435 @default.
- W2024295268 cites W1997699460 @default.
- W2024295268 cites W1997740633 @default.
- W2024295268 cites W1999166425 @default.
- W2024295268 cites W1999650791 @default.
- W2024295268 cites W2003118327 @default.
- W2024295268 cites W2012508148 @default.
- W2024295268 cites W2014843562 @default.
- W2024295268 cites W2020238334 @default.
- W2024295268 cites W2024174234 @default.
- W2024295268 cites W2027120416 @default.
- W2024295268 cites W2033006368 @default.
- W2024295268 cites W2036615960 @default.
- W2024295268 cites W2041188574 @default.
- W2024295268 cites W2058503963 @default.
- W2024295268 cites W2058567016 @default.
- W2024295268 cites W2059798059 @default.
- W2024295268 cites W2063010637 @default.
- W2024295268 cites W2077600000 @default.
- W2024295268 cites W2088291423 @default.
- W2024295268 cites W2102773142 @default.
- W2024295268 cites W2142433047 @default.
- W2024295268 cites W2149886501 @default.
- W2024295268 cites W2155285827 @default.
- W2024295268 cites W2156174515 @default.
- W2024295268 cites W2163792365 @default.
- W2024295268 cites W2166683822 @default.
- W2024295268 cites W4250233962 @default.
- W2024295268 cites W2085783185 @default.
- W2024295268 doi "https://doi.org/10.1177/1933719109343787" @default.
- W2024295268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19801536" @default.
- W2024295268 hasPublicationYear "2009" @default.
- W2024295268 type Work @default.
- W2024295268 sameAs 2024295268 @default.
- W2024295268 citedByCount "27" @default.
- W2024295268 countsByYear W20242952682012 @default.
- W2024295268 countsByYear W20242952682013 @default.
- W2024295268 countsByYear W20242952682015 @default.
- W2024295268 countsByYear W20242952682016 @default.
- W2024295268 countsByYear W20242952682017 @default.
- W2024295268 countsByYear W20242952682018 @default.
- W2024295268 countsByYear W20242952682019 @default.
- W2024295268 countsByYear W20242952682021 @default.
- W2024295268 countsByYear W20242952682022 @default.
- W2024295268 countsByYear W20242952682023 @default.
- W2024295268 crossrefType "journal-article" @default.
- W2024295268 hasAuthorship W2024295268A5030750604 @default.
- W2024295268 hasAuthorship W2024295268A5066592719 @default.
- W2024295268 hasAuthorship W2024295268A5072831168 @default.
- W2024295268 hasAuthorship W2024295268A5074018044 @default.
- W2024295268 hasBestOaLocation W20242952682 @default.
- W2024295268 hasConcept C10335311 @default.
- W2024295268 hasConcept C1122143 @default.
- W2024295268 hasConcept C126322002 @default.
- W2024295268 hasConcept C134018914 @default.
- W2024295268 hasConcept C163415756 @default.
- W2024295268 hasConcept C170493617 @default.
- W2024295268 hasConcept C185592680 @default.
- W2024295268 hasConcept C2775864247 @default.
- W2024295268 hasConcept C2776166919 @default.
- W2024295268 hasConcept C2776885963 @default.
- W2024295268 hasConcept C2777785214 @default.
- W2024295268 hasConcept C2778938600 @default.
- W2024295268 hasConcept C2779941686 @default.
- W2024295268 hasConcept C2910759140 @default.
- W2024295268 hasConcept C34400551 @default.
- W2024295268 hasConcept C39133596 @default.
- W2024295268 hasConcept C53910766 @default.
- W2024295268 hasConcept C71924100 @default.
- W2024295268 hasConcept C98274493 @default.
- W2024295268 hasConceptScore W2024295268C10335311 @default.
- W2024295268 hasConceptScore W2024295268C1122143 @default.
- W2024295268 hasConceptScore W2024295268C126322002 @default.
- W2024295268 hasConceptScore W2024295268C134018914 @default.
- W2024295268 hasConceptScore W2024295268C163415756 @default.
- W2024295268 hasConceptScore W2024295268C170493617 @default.
- W2024295268 hasConceptScore W2024295268C185592680 @default.
- W2024295268 hasConceptScore W2024295268C2775864247 @default.