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• W2024296036 abstract "Background: Autologous platelet-rich matrices can be an aid in surgery by promoting and accelerating tissue healing because of the release of growth factors including transforming growth factor (TGF)-β1 and platelet-derived growth factor (PDGF) from platelet α-granules. Methods: PDGF and TGF-β1 were quantified in supernatants collected from platelet-rich matrices prepared in vitro (n = 45 donors) and they correlated with the number of platelets and showed a constant ratio (p < 0.05). Tendon cells in culture were exposed to the supernatants (n = 4 donors) from either platelet-rich or platelet-poor matrices, differing in their content of platelet-secreted molecules. These treatments were modified by either neutralizing or adding PDGF or TGF-β1. Effects were compared in terms of proliferation, procollagen I, vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF) production. Results: PDGF was a partial contributor to cell proliferation, whereas exogenous TGF-β1 acted as a negative modulator (p < 0.05). The production of type I collagen was similar regardless of differences in the concentration of TGF-β1. Moreover, addition of exogenous TGF-β1 promoted a significant increase in collagen synthesis only in the absence of other platelet-released substances (p < 0.05). Exogenous TGF-β1 increased the synthesis of VEGF and simultaneously abolished the production of HGF. Furthermore, antibody-mediated neutralization of TGF-β1 induced a decrease in VEGF synthesis and concomitantly a substantial production of HGF (p < 0.05). Conclusion: The balance between TGF-β1 and the pools of platelet-secreted molecules may have important therapeutic implications in the control of angiogenesis and fibrosis." @default.
• W2024296036 created "2016-06-24" @default.
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• W2024296036 date "2007-03-01" @default.
• W2024296036 modified "2023-10-17" @default.
• W2024296036 title "Reciprocal Actions of Platelet-Secreted TGF-??1 on the Production of VEGF and HGF by Human Tendon Cells" @default.
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• W2024296036 doi "https://doi.org/10.1097/01.prs.0000255543.43695.1d" @default.
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