FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024296976> ?p ?o ?g. }

• W2024296976 endingPage "73" @default.
• W2024296976 startingPage "59" @default.
• W2024296976 abstract "DFsc is a single chain de novo designed four-helix bundle peptide that mimics the core protein fold and primary ligand set of various binuclear non-heme iron enzymes. DFsc and the E11D, Y51L, and Y18F single amino acid variants have been studied using a combination of near-IR circular dichroism (CD), magnetic circular dichroism (MCD), variable temperature variable field MCD (VTVH MCD), and X-ray absorption (XAS) spectroscopies. The biferrous sites are all weakly antiferromagnetically coupled with μ-1,3 carboxylate bridges and one 4-coordinate and one 5-coordinate Fe, very similar to the active site of class I ribonucleotide reductase (R2) providing open coordination positions on both irons for dioxygen to bridge. From perturbations of the MCD and VTVH MCD the iron proximal to Y51 can be assigned as the 4-coordinate center, and XAS results show that Y51 is not bound to this iron in the reduced state. The two open coordination positions on one iron in the biferrous state would become occupied by dioxygen and Y51 along the O2 reaction coordinate. Subsequent binding of Y51 functions as an internal spectral probe of the O2 reaction and as a proton source that would promote loss of H2O2. Coordination by a ligand that functions as a proton source could be a structural mechanism used by natural binuclear iron enzymes to drive their reactions past peroxo biferric level intermediates." @default.
• W2024296976 created "2016-06-24" @default.
• W2024296976 creator A5014518485 @default.
• W2024296976 creator A5021623971 @default.
• W2024296976 creator A5024342453 @default.
• W2024296976 creator A5035672814 @default.
• W2024296976 creator A5050821390 @default.
• W2024296976 creator A5059054001 @default.
• W2024296976 creator A5072260476 @default.
• W2024296976 creator A5080517856 @default.
• W2024296976 date "2008-12-17" @default.
• W2024296976 modified "2023-10-16" @default.
• W2024296976 title "Spectroscopic Definition of the Biferrous and Biferric Sites in <i>de Novo</i> Designed Four-Helix Bundle DFsc Peptides: Implications for O₂ Reactivity of Binuclear Non-Heme Iron Enzymes" @default.
• W2024296976 cites W108059199 @default.
• W2024296976 cites W1482589774 @default.
• W2024296976 cites W170526692 @default.
• W2024296976 cites W1834249524 @default.
• W2024296976 cites W1965891140 @default.
• W2024296976 cites W1968613802 @default.
• W2024296976 cites W1973614655 @default.
• W2024296976 cites W1981366516 @default.
• W2024296976 cites W1981704948 @default.
• W2024296976 cites W1983684033 @default.
• W2024296976 cites W1985440805 @default.
• W2024296976 cites W1988703402 @default.
• W2024296976 cites W1992396311 @default.
• W2024296976 cites W1992510556 @default.
• W2024296976 cites W1993284652 @default.
• W2024296976 cites W1996024525 @default.
• W2024296976 cites W1999357474 @default.
• W2024296976 cites W2000732917 @default.
• W2024296976 cites W2009962363 @default.
• W2024296976 cites W2011099080 @default.
• W2024296976 cites W2011169834 @default.
• W2024296976 cites W2017356987 @default.
• W2024296976 cites W2023491496 @default.
• W2024296976 cites W2028462347 @default.
• W2024296976 cites W2029914535 @default.
• W2024296976 cites W2039359269 @default.
• W2024296976 cites W2044058803 @default.
• W2024296976 cites W2044173651 @default.
• W2024296976 cites W2045039660 @default.
• W2024296976 cites W2048739223 @default.
• W2024296976 cites W2049601847 @default.
• W2024296976 cites W2050823973 @default.
• W2024296976 cites W2051729024 @default.
• W2024296976 cites W2053871428 @default.
• W2024296976 cites W2058799785 @default.
• W2024296976 cites W2059926907 @default.
• W2024296976 cites W2063383175 @default.
• W2024296976 cites W2064447766 @default.
• W2024296976 cites W2066173818 @default.
• W2024296976 cites W2067405773 @default.
• W2024296976 cites W2068786943 @default.
• W2024296976 cites W2073025326 @default.
• W2024296976 cites W2077077301 @default.
• W2024296976 cites W2077749836 @default.
• W2024296976 cites W2077934271 @default.
• W2024296976 cites W2078171437 @default.
• W2024296976 cites W2081470582 @default.
• W2024296976 cites W2083114864 @default.
• W2024296976 cites W2084919208 @default.
• W2024296976 cites W2087027286 @default.
• W2024296976 cites W2089647812 @default.
• W2024296976 cites W2090265120 @default.
• W2024296976 cites W2092102609 @default.
• W2024296976 cites W2107552656 @default.
• W2024296976 cites W2112868721 @default.
• W2024296976 cites W2124129917 @default.
• W2024296976 cites W2129832199 @default.
• W2024296976 cites W2135361855 @default.
• W2024296976 cites W2165242624 @default.
• W2024296976 cites W2166060486 @default.
• W2024296976 cites W2172844043 @default.
• W2024296976 cites W2949240035 @default.
• W2024296976 cites W80527890 @default.
• W2024296976 doi "https://doi.org/10.1021/bi8016087" @default.
• W2024296976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2660568" @default.
• W2024296976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19090676" @default.
• W2024296976 hasPublicationYear "2008" @default.
• W2024296976 type Work @default.
• W2024296976 sameAs 2024296976 @default.
• W2024296976 citedByCount "25" @default.
• W2024296976 countsByYear W20242969762012 @default.
• W2024296976 countsByYear W20242969762013 @default.
• W2024296976 countsByYear W20242969762014 @default.
• W2024296976 countsByYear W20242969762015 @default.
• W2024296976 countsByYear W20242969762016 @default.
• W2024296976 countsByYear W20242969762017 @default.
• W2024296976 countsByYear W20242969762018 @default.
• W2024296976 countsByYear W20242969762019 @default.
• W2024296976 countsByYear W20242969762020 @default.
• W2024296976 countsByYear W20242969762022 @default.
• W2024296976 crossrefType "journal-article" @default.
• W2024296976 hasAuthorship W2024296976A5014518485 @default.
• W2024296976 hasAuthorship W2024296976A5021623971 @default.
• W2024296976 hasAuthorship W2024296976A5024342453 @default.
• W2024296976 hasAuthorship W2024296976A5035672814 @default.

• next