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• W2024298292 abstract "The chronic stress of caregiving may lead to sympathetic nervous system activation and immune suppression. β2-adrenergic receptors are expressed on all immune cells and contribute to the stress-induced loss of immune-cell function. The authors examined the effects of being a spousal caregiver of a patient with Alzheimer disease (AD) on the lymphocyte β2-adrenergic receptor. One hundred and six women and men, spousal caregivers and non-caregivers, participated (mean age: 71.5 years). Caregivers were classified as either vulnerable or non-vulnerable on the basis of the amount of care required by the patient relative to the amount of respite the caregiver received during the previous 6 months. β2-adrenergic receptor sensitivity (cyclic-AMP response to isoproterenol stimulation) and density (radioligand binding) were determined by use of whole lymphocytes. Vulnerable caregivers had reduced β2-adrenergic receptor sensitivity and density when compared with their non-vulnerable counterparts or with non-caregivers. The findings indicate that for more vulnerable caregivers, the stress of caregiving leads to a loss of lymphocyte β2-adrenergic receptors. This finding may be relevant to previous observations of clinically-relevant reduced immunity in highly stressed caregivers of AD patients." @default.
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• W2024298292 date "2004-05-01" @default.
• W2024298292 modified "2023-09-23" @default.
• W2024298292 title "Vulnerable Caregivers of Alzheimer Disease Patients Have a Deficit in β2-Adrenergic Receptor Sensitivity and Density" @default.
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• W2024298292 doi "https://doi.org/10.1097/00019442-200405000-00007" @default.
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