Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024299014> ?p ?o ?g. }
- W2024299014 endingPage "1990" @default.
- W2024299014 startingPage "1967" @default.
- W2024299014 abstract "Supercritical or near-critical fluid processes for generating microparticles have enjoyed considerable attention in the past decade or so, with good success for substances soluble in supercritical fluids or organic solvents. In this review, we survey their application to the production of protein particles. A recently developed process known as CO2-assisted nebulization with a Bubble Dryer® (CAN-BD) has been demonstrated to have broad applicability to small-molecule as well as macromolecule substances (including therapeutic proteins). The principles of CAN-BD are discussed as well as the stabilization, micronization and drying of a wide variety of materials. More detailed case studies are presented for three proteins, two of which are of therapeutic interest: anti-CD4 antibody (rheumatoid arthritis), α1-antitrypsin (cystic fibrosis and emphysema), and trypsinogen (a model enzyme). Dry powders were formed in which stability and activity are maintained and which are fine enough to be inhaled and reach the deep lung. Enhancement of apparent activity after CAN-BD processing was also observed in some formulation and processing conditions." @default.
- W2024299014 created "2016-06-24" @default.
- W2024299014 creator A5008365437 @default.
- W2024299014 creator A5020210299 @default.
- W2024299014 creator A5027063701 @default.
- W2024299014 creator A5077703179 @default.
- W2024299014 creator A5082095962 @default.
- W2024299014 creator A5085315404 @default.
- W2024299014 date "2008-06-26" @default.
- W2024299014 modified "2023-09-26" @default.
- W2024299014 title "Preparation of Active Proteins, Vaccines and Pharmaceuticals as Fine Powders using Supercritical or Near-Critical Fluids" @default.
- W2024299014 cites W1493124133 @default.
- W2024299014 cites W1508836098 @default.
- W2024299014 cites W1567072241 @default.
- W2024299014 cites W188491214 @default.
- W2024299014 cites W1963830275 @default.
- W2024299014 cites W1963840200 @default.
- W2024299014 cites W1965358147 @default.
- W2024299014 cites W1967769926 @default.
- W2024299014 cites W1970044713 @default.
- W2024299014 cites W1971228298 @default.
- W2024299014 cites W1972646050 @default.
- W2024299014 cites W1977996370 @default.
- W2024299014 cites W1979839167 @default.
- W2024299014 cites W1979926181 @default.
- W2024299014 cites W1981334511 @default.
- W2024299014 cites W1982303551 @default.
- W2024299014 cites W1987206719 @default.
- W2024299014 cites W1991440683 @default.
- W2024299014 cites W1992845677 @default.
- W2024299014 cites W1993594113 @default.
- W2024299014 cites W1997059713 @default.
- W2024299014 cites W1999478978 @default.
- W2024299014 cites W1999485999 @default.
- W2024299014 cites W2004217006 @default.
- W2024299014 cites W2004258352 @default.
- W2024299014 cites W2012358672 @default.
- W2024299014 cites W2016861978 @default.
- W2024299014 cites W2023511836 @default.
- W2024299014 cites W2028316064 @default.
- W2024299014 cites W2029720457 @default.
- W2024299014 cites W2031112016 @default.
- W2024299014 cites W2032299999 @default.
- W2024299014 cites W2046331902 @default.
- W2024299014 cites W2050240375 @default.
- W2024299014 cites W2051932872 @default.
- W2024299014 cites W2054260828 @default.
- W2024299014 cites W2054371537 @default.
- W2024299014 cites W2055974743 @default.
- W2024299014 cites W2057770903 @default.
- W2024299014 cites W2059564760 @default.
- W2024299014 cites W2060742603 @default.
- W2024299014 cites W2066777346 @default.
- W2024299014 cites W2067555392 @default.
- W2024299014 cites W2071646629 @default.
- W2024299014 cites W2075791526 @default.
- W2024299014 cites W2077231187 @default.
- W2024299014 cites W2079274958 @default.
- W2024299014 cites W2084259523 @default.
- W2024299014 cites W2093505255 @default.
- W2024299014 cites W2094206128 @default.
- W2024299014 cites W2109702896 @default.
- W2024299014 cites W2114190596 @default.
- W2024299014 cites W2123188699 @default.
- W2024299014 cites W2131565982 @default.
- W2024299014 cites W2142360770 @default.
- W2024299014 cites W2144357110 @default.
- W2024299014 cites W2153230127 @default.
- W2024299014 cites W2159426997 @default.
- W2024299014 cites W2162837046 @default.
- W2024299014 cites W2163106863 @default.
- W2024299014 cites W2164492260 @default.
- W2024299014 cites W2164929350 @default.
- W2024299014 cites W2169363338 @default.
- W2024299014 cites W2183649757 @default.
- W2024299014 cites W2219743927 @default.
- W2024299014 cites W2292153062 @default.
- W2024299014 cites W2474453147 @default.
- W2024299014 cites W2495940708 @default.
- W2024299014 cites W2808097441 @default.
- W2024299014 cites W285828261 @default.
- W2024299014 cites W4211127139 @default.
- W2024299014 cites W4214600967 @default.
- W2024299014 cites W4234255481 @default.
- W2024299014 cites W4241623314 @default.
- W2024299014 cites W4254381403 @default.
- W2024299014 cites W943181251 @default.
- W2024299014 doi "https://doi.org/10.1007/s11095-008-9575-6" @default.
- W2024299014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2515571" @default.
- W2024299014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18581212" @default.
- W2024299014 hasPublicationYear "2008" @default.
- W2024299014 type Work @default.
- W2024299014 sameAs 2024299014 @default.
- W2024299014 citedByCount "65" @default.
- W2024299014 countsByYear W20242990142012 @default.
- W2024299014 countsByYear W20242990142013 @default.
- W2024299014 countsByYear W20242990142014 @default.
- W2024299014 countsByYear W20242990142015 @default.