FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024300963> ?p ?o ?g. }

• W2024300963 endingPage "590" @default.
• W2024300963 startingPage "583" @default.
• W2024300963 abstract "Tea (Camellia sinensis (L.) O. Kuntze, Theaceae) flowers possess many physiological functions and have been used in traditional medicines for deodorization, skin care, cough suppressant and expectorant in China. However, there is a little information about its possible toxicity. The present investigation was carried out to evaluate the safety of tea flower extract by mutagenicity and acute and subchronic toxicity studies. Mutagenicity of tea flower extract was evaluated by the Ames test in Salmonella typhimurium strains TA97, TA98, TA100 and TA102 at concentrations of 0.008, 0.04, 0.2, 1.0, 5.0 mg/plate. In the acute toxicity study, Sprague–Dawley rats were administered a single dose of 12.0 g/kg of body weight by gavage, and were monitored for 14 days. In the subchronic toxicity study, tea flower extract was administered by gavage at doses of 1.0, 2.0 and 4.0 g/kg body weight daily for 13 weeks to Sprague–Dawley rats. In the Ames test, there was no mutagenic effect of tea flower extract (up to 5.0 mg/plate) towards four tested strains (TA97, TA98, TA100, TA102), with or without metabolic activation (S9). In the acute toxicity study, all animals gained weight and appeared active and normal, so the LD50 value must be >12.0 g/kg body weight. In the subchronic toxicity study, no dose-related effects on survival, growth, hematology, blood chemistry, organ weights, or pathologic lesions were observed. These results indicate that tea flower extract does not possess mutagenic potential, and that both acute and subchronic toxicity towards animals is very low. A no-observed adverse-effect level (NOAEL) for tea flower extract is 4.0 g/kg bw/day for rats under the conditions of this study." @default.
• W2024300963 created "2016-06-24" @default.
• W2024300963 creator A5001560890 @default.
• W2024300963 creator A5011101310 @default.
• W2024300963 creator A5047113062 @default.
• W2024300963 creator A5067069882 @default.
• W2024300963 creator A5067995522 @default.
• W2024300963 creator A5070574208 @default.
• W2024300963 date "2011-01-01" @default.
• W2024300963 modified "2023-09-28" @default.
• W2024300963 title "Safety evaluation of tea (Camellia sinensis (L.) O. Kuntze) flower extract: Assessment of mutagenicity, and acute and subchronic toxicity in rats" @default.
• W2024300963 cites W119198626 @default.
• W2024300963 cites W136823849 @default.
• W2024300963 cites W1926759975 @default.
• W2024300963 cites W1964041276 @default.
• W2024300963 cites W1972281991 @default.
• W2024300963 cites W1972722981 @default.
• W2024300963 cites W1973195696 @default.
• W2024300963 cites W1973564152 @default.
• W2024300963 cites W1980407534 @default.
• W2024300963 cites W1983207054 @default.
• W2024300963 cites W1987327082 @default.
• W2024300963 cites W2000519650 @default.
• W2024300963 cites W2002769802 @default.
• W2024300963 cites W2005156172 @default.
• W2024300963 cites W2008292170 @default.
• W2024300963 cites W2036533735 @default.
• W2024300963 cites W2039043591 @default.
• W2024300963 cites W2044253412 @default.
• W2024300963 cites W2048900230 @default.
• W2024300963 cites W2052292049 @default.
• W2024300963 cites W2056525414 @default.
• W2024300963 cites W2069017282 @default.
• W2024300963 cites W2070422796 @default.
• W2024300963 cites W2090506723 @default.
• W2024300963 cites W2091129884 @default.
• W2024300963 cites W2091652052 @default.
• W2024300963 cites W2112836939 @default.
• W2024300963 cites W2116597521 @default.
• W2024300963 cites W2127157107 @default.
• W2024300963 cites W2128331833 @default.
• W2024300963 cites W2159957679 @default.
• W2024300963 doi "https://doi.org/10.1016/j.jep.2010.02.030" @default.
• W2024300963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21034804" @default.
• W2024300963 hasPublicationYear "2011" @default.
• W2024300963 type Work @default.
• W2024300963 sameAs 2024300963 @default.
• W2024300963 citedByCount "27" @default.
• W2024300963 countsByYear W20243009632012 @default.
• W2024300963 countsByYear W20243009632013 @default.
• W2024300963 countsByYear W20243009632014 @default.
• W2024300963 countsByYear W20243009632015 @default.
• W2024300963 countsByYear W20243009632016 @default.
• W2024300963 countsByYear W20243009632017 @default.
• W2024300963 countsByYear W20243009632018 @default.
• W2024300963 countsByYear W20243009632019 @default.
• W2024300963 countsByYear W20243009632020 @default.
• W2024300963 countsByYear W20243009632021 @default.
• W2024300963 countsByYear W20243009632022 @default.
• W2024300963 countsByYear W20243009632023 @default.
• W2024300963 crossrefType "journal-article" @default.
• W2024300963 hasAuthorship W2024300963A5001560890 @default.
• W2024300963 hasAuthorship W2024300963A5011101310 @default.
• W2024300963 hasAuthorship W2024300963A5047113062 @default.
• W2024300963 hasAuthorship W2024300963A5067069882 @default.
• W2024300963 hasAuthorship W2024300963A5067995522 @default.
• W2024300963 hasAuthorship W2024300963A5070574208 @default.
• W2024300963 hasConcept C116263406 @default.
• W2024300963 hasConcept C117632636 @default.
• W2024300963 hasConcept C126322002 @default.
• W2024300963 hasConcept C147583825 @default.
• W2024300963 hasConcept C185592680 @default.
• W2024300963 hasConcept C2780068710 @default.
• W2024300963 hasConcept C2781065037 @default.
• W2024300963 hasConcept C29730261 @default.
• W2024300963 hasConcept C2992816389 @default.
• W2024300963 hasConcept C31903555 @default.
• W2024300963 hasConcept C33070731 @default.
• W2024300963 hasConcept C523546767 @default.
• W2024300963 hasConcept C54355233 @default.
• W2024300963 hasConcept C556039675 @default.
• W2024300963 hasConcept C59822182 @default.
• W2024300963 hasConcept C71924100 @default.
• W2024300963 hasConcept C86803240 @default.
• W2024300963 hasConcept C98274493 @default.
• W2024300963 hasConceptScore W2024300963C116263406 @default.
• W2024300963 hasConceptScore W2024300963C117632636 @default.
• W2024300963 hasConceptScore W2024300963C126322002 @default.
• W2024300963 hasConceptScore W2024300963C147583825 @default.
• W2024300963 hasConceptScore W2024300963C185592680 @default.
• W2024300963 hasConceptScore W2024300963C2780068710 @default.
• W2024300963 hasConceptScore W2024300963C2781065037 @default.
• W2024300963 hasConceptScore W2024300963C29730261 @default.
• W2024300963 hasConceptScore W2024300963C2992816389 @default.
• W2024300963 hasConceptScore W2024300963C31903555 @default.
• W2024300963 hasConceptScore W2024300963C33070731 @default.
• W2024300963 hasConceptScore W2024300963C523546767 @default.
• W2024300963 hasConceptScore W2024300963C54355233 @default.

• next