FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024300979> ?p ?o ?g. }

• W2024300979 endingPage "1682" @default.
• W2024300979 startingPage "1673" @default.
• W2024300979 abstract "Mammals mount a rapid inflammatory response to gram-negative bacteria by recognizing lipopolysaccharide (LPS, endotoxin). LPS binds to CD14, and the resulting LPS-CD14 complex induces synthesis of cytokines and up-regulation of adhesion molecules in a variety of cell types. Gram-positive bacteria provoke a very similar inflammatory response, but the molecules that provoke innate responses to these bacteria have not been defined. Here we show that protein-free, phenol extracts of Staphylococcus aureus contain a minor component that stimulates adhesion of neutrophils and cytokine production in monocytes and in the astrocytoma cell line, U373. Responses to this component do not absolutely require CD14, but addition of soluble CD14 enhances sensitivity of U373 cells by up to 100-fold, and blocking CD14 on monocytes decreases sensitivity nearly 1,000-fold. Deletion of residues 57-64 of CD14, which are required for responses to LPS, also eliminates CD14-dependent responses to S. aureus molecules. The stimulatory component of S. aureus binds CD14 and blocks binding of radioactive LPS. Unlike LPS, the activity of S. aureus molecules was neither enhanced by LPS binding protein nor inhibited by bactericidal/permeability increasing protein. The active factor in extracts of S. aureus is also structurally and functionally distinct from the abundant species known as lipoteichoic acid (LTA). Cell-stimulating activity fractionates differently from LTA on a reverse-phase column, pure LTA fails to stimulate cells, and LTA antagonizes the action of LPS in assays of IL-6 production. These studies suggest that mammals may use CD14 in innate responses to both gram-negative and gram-positive bacteria, and that gram-positive bacteria may contain an apparently unique, CD14-binding species that initiates cellular responses." @default.
• W2024300979 created "2016-06-24" @default.
• W2024300979 creator A5045607662 @default.
• W2024300979 creator A5048225464 @default.
• W2024300979 creator A5056989654 @default.
• W2024300979 creator A5076210539 @default.
• W2024300979 creator A5086752031 @default.
• W2024300979 date "1995-12-01" @default.
• W2024300979 modified "2023-10-16" @default.
• W2024300979 title "Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses." @default.
• W2024300979 cites W104624964 @default.
• W2024300979 cites W1158525792 @default.
• W2024300979 cites W1499532983 @default.
• W2024300979 cites W1523183151 @default.
• W2024300979 cites W1539738291 @default.
• W2024300979 cites W1552585184 @default.
• W2024300979 cites W1761041803 @default.
• W2024300979 cites W1794719966 @default.
• W2024300979 cites W187404486 @default.
• W2024300979 cites W1901037327 @default.
• W2024300979 cites W1955931243 @default.
• W2024300979 cites W1964235895 @default.
• W2024300979 cites W1967209921 @default.
• W2024300979 cites W1976485230 @default.
• W2024300979 cites W1998380451 @default.
• W2024300979 cites W2002475242 @default.
• W2024300979 cites W2006515599 @default.
• W2024300979 cites W2015211989 @default.
• W2024300979 cites W2023314419 @default.
• W2024300979 cites W2029157767 @default.
• W2024300979 cites W2037773910 @default.
• W2024300979 cites W2041895917 @default.
• W2024300979 cites W2057714107 @default.
• W2024300979 cites W2058352235 @default.
• W2024300979 cites W2064626913 @default.
• W2024300979 cites W2067294390 @default.
• W2024300979 cites W2075369004 @default.
• W2024300979 cites W2078144425 @default.
• W2024300979 cites W2081445505 @default.
• W2024300979 cites W2084351593 @default.
• W2024300979 cites W2092266394 @default.
• W2024300979 cites W2100762885 @default.
• W2024300979 cites W2106161615 @default.
• W2024300979 cites W2109350206 @default.
• W2024300979 cites W2110850919 @default.
• W2024300979 cites W2122327998 @default.
• W2024300979 cites W2124695463 @default.
• W2024300979 cites W2135536286 @default.
• W2024300979 cites W2141130289 @default.
• W2024300979 cites W2144828448 @default.
• W2024300979 cites W2146732421 @default.
• W2024300979 cites W2154043653 @default.
• W2024300979 cites W2159647500 @default.
• W2024300979 cites W2163147488 @default.
• W2024300979 cites W2170495397 @default.
• W2024300979 cites W2322039271 @default.
• W2024300979 cites W4242542423 @default.
• W2024300979 doi "https://doi.org/10.1084/jem.182.6.1673" @default.
• W2024300979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2192236" @default.
• W2024300979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7500012" @default.
• W2024300979 hasPublicationYear "1995" @default.
• W2024300979 type Work @default.
• W2024300979 sameAs 2024300979 @default.
• W2024300979 citedByCount "170" @default.
• W2024300979 countsByYear W20243009792012 @default.
• W2024300979 countsByYear W20243009792013 @default.
• W2024300979 countsByYear W20243009792014 @default.
• W2024300979 countsByYear W20243009792015 @default.
• W2024300979 countsByYear W20243009792016 @default.
• W2024300979 countsByYear W20243009792018 @default.
• W2024300979 countsByYear W20243009792020 @default.
• W2024300979 countsByYear W20243009792021 @default.
• W2024300979 countsByYear W20243009792022 @default.
• W2024300979 countsByYear W20243009792023 @default.
• W2024300979 crossrefType "journal-article" @default.
• W2024300979 hasAuthorship W2024300979A5045607662 @default.
• W2024300979 hasAuthorship W2024300979A5048225464 @default.
• W2024300979 hasAuthorship W2024300979A5056989654 @default.
• W2024300979 hasAuthorship W2024300979A5076210539 @default.
• W2024300979 hasAuthorship W2024300979A5086752031 @default.
• W2024300979 hasBestOaLocation W20243009791 @default.
• W2024300979 hasConcept C136449434 @default.
• W2024300979 hasConcept C185592680 @default.
• W2024300979 hasConcept C203014093 @default.
• W2024300979 hasConcept C2778513237 @default.
• W2024300979 hasConcept C2778754761 @default.
• W2024300979 hasConcept C2779489039 @default.
• W2024300979 hasConcept C523546767 @default.
• W2024300979 hasConcept C54355233 @default.
• W2024300979 hasConcept C6977687 @default.
• W2024300979 hasConcept C86803240 @default.
• W2024300979 hasConcept C8891405 @default.
• W2024300979 hasConcept C89423630 @default.
• W2024300979 hasConcept C95444343 @default.
• W2024300979 hasConceptScore W2024300979C136449434 @default.
• W2024300979 hasConceptScore W2024300979C185592680 @default.
• W2024300979 hasConceptScore W2024300979C203014093 @default.
• W2024300979 hasConceptScore W2024300979C2778513237 @default.

• next