FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024301095> ?p ?o ?g. }

• W2024301095 endingPage "9167" @default.
• W2024301095 startingPage "9157" @default.
• W2024301095 abstract "Copper plays a fundamental role in regulating cell growth. Many types of human cancer tissues have higher copper levels than normal tissues. Copper can also induce gene expression. However, transcription factors that mediate copper-induced cell proliferation have not been identified in mammals. Here we show that antioxidant-1 (Atox1), previously appreciated as a copper chaperone, represents a novel copper-dependent transcription factor that mediates copper-induced cell proliferation. Stimulation of mouse embryonic fibroblasts (MEFs) with copper markedly increased cell proliferation, cyclin D1 expression, and entry into S phase, which were completely abolished in Atox1(-/-) MEFs. Promoter analysis and EMSA revealed that copper stimulates the Atox1 binding to a previously undescribed cis element in the cyclin D1 promoter. The ChIP assay confirms that copper stimulates Atox1 binding to the DNA in vivo. Transfection of Atox1 fused to the DNA-binding domain of Gal4 demonstrated a copper-dependent transactivation in various cell types, including endothelial and cancer cells. Furthermore, Atox1 translocated to the nucleus in response to copper through its highly conserved C-terminal KKTGK motif and N-terminal copper-binding sites. Finally, the functional role of nuclear Atox1 is demonstrated by the observation that re-expression of nuclear-targeted Atox1 in Atox1(-/-) MEFs rescued the defective copper-induced cell proliferation. Thus, Atox1 functions as a novel transcription factor that, when activated by copper, undergoes nuclear translocation, DNA binding, and transactivation, thereby contributing to cell proliferation." @default.
• W2024301095 created "2016-06-24" @default.
• W2024301095 creator A5009324730 @default.
• W2024301095 creator A5012723601 @default.
• W2024301095 creator A5021137697 @default.
• W2024301095 creator A5036537743 @default.
• W2024301095 creator A5039032405 @default.
• W2024301095 creator A5047997569 @default.
• W2024301095 creator A5072960074 @default.
• W2024301095 creator A5081426595 @default.
• W2024301095 creator A5082860312 @default.
• W2024301095 creator A5085309946 @default.
• W2024301095 date "2008-04-01" @default.
• W2024301095 modified "2023-10-18" @default.
• W2024301095 title "Novel Role of Antioxidant-1 (Atox1) as a Copper-dependent Transcription Factor Involved in Cell Proliferation" @default.
• W2024301095 cites W1496283406 @default.
• W2024301095 cites W1520684992 @default.
• W2024301095 cites W1600424873 @default.
• W2024301095 cites W1900581805 @default.
• W2024301095 cites W1963874808 @default.
• W2024301095 cites W1994007675 @default.
• W2024301095 cites W2004471846 @default.
• W2024301095 cites W2011444292 @default.
• W2024301095 cites W2023825554 @default.
• W2024301095 cites W2027328046 @default.
• W2024301095 cites W2029202068 @default.
• W2024301095 cites W2029652412 @default.
• W2024301095 cites W2031935607 @default.
• W2024301095 cites W2033722975 @default.
• W2024301095 cites W2045616069 @default.
• W2024301095 cites W2049604444 @default.
• W2024301095 cites W2050692858 @default.
• W2024301095 cites W2054642157 @default.
• W2024301095 cites W2066547209 @default.
• W2024301095 cites W2080677621 @default.
• W2024301095 cites W2083615209 @default.
• W2024301095 cites W2090273010 @default.
• W2024301095 cites W2096188077 @default.
• W2024301095 cites W2102604313 @default.
• W2024301095 cites W2102744645 @default.
• W2024301095 cites W2103378158 @default.
• W2024301095 cites W2116751283 @default.
• W2024301095 cites W2116764617 @default.
• W2024301095 cites W2123863340 @default.
• W2024301095 cites W2130781987 @default.
• W2024301095 cites W2134363913 @default.
• W2024301095 cites W2140520381 @default.
• W2024301095 cites W2144825640 @default.
• W2024301095 cites W2146890885 @default.
• W2024301095 cites W2149082710 @default.
• W2024301095 cites W2154883764 @default.
• W2024301095 cites W2164363791 @default.
• W2024301095 cites W2316964745 @default.
• W2024301095 doi "https://doi.org/10.1074/jbc.m709463200" @default.
• W2024301095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2431038" @default.
• W2024301095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18245776" @default.
• W2024301095 hasPublicationYear "2008" @default.
• W2024301095 type Work @default.
• W2024301095 sameAs 2024301095 @default.
• W2024301095 citedByCount "209" @default.
• W2024301095 countsByYear W20243010952012 @default.
• W2024301095 countsByYear W20243010952013 @default.
• W2024301095 countsByYear W20243010952014 @default.
• W2024301095 countsByYear W20243010952015 @default.
• W2024301095 countsByYear W20243010952016 @default.
• W2024301095 countsByYear W20243010952017 @default.
• W2024301095 countsByYear W20243010952018 @default.
• W2024301095 countsByYear W20243010952019 @default.
• W2024301095 countsByYear W20243010952020 @default.
• W2024301095 countsByYear W20243010952021 @default.
• W2024301095 countsByYear W20243010952022 @default.
• W2024301095 countsByYear W20243010952023 @default.
• W2024301095 crossrefType "journal-article" @default.
• W2024301095 hasAuthorship W2024301095A5009324730 @default.
• W2024301095 hasAuthorship W2024301095A5012723601 @default.
• W2024301095 hasAuthorship W2024301095A5021137697 @default.
• W2024301095 hasAuthorship W2024301095A5036537743 @default.
• W2024301095 hasAuthorship W2024301095A5039032405 @default.
• W2024301095 hasAuthorship W2024301095A5047997569 @default.
• W2024301095 hasAuthorship W2024301095A5072960074 @default.
• W2024301095 hasAuthorship W2024301095A5081426595 @default.
• W2024301095 hasAuthorship W2024301095A5082860312 @default.
• W2024301095 hasAuthorship W2024301095A5085309946 @default.
• W2024301095 hasBestOaLocation W20243010951 @default.
• W2024301095 hasConcept C104317684 @default.
• W2024301095 hasConcept C1292079 @default.
• W2024301095 hasConcept C1491633281 @default.
• W2024301095 hasConcept C153911025 @default.
• W2024301095 hasConcept C185592680 @default.
• W2024301095 hasConcept C199835354 @default.
• W2024301095 hasConcept C29537977 @default.
• W2024301095 hasConcept C33987129 @default.
• W2024301095 hasConcept C55493867 @default.
• W2024301095 hasConcept C62112901 @default.
• W2024301095 hasConcept C86339819 @default.
• W2024301095 hasConcept C86803240 @default.
• W2024301095 hasConcept C95444343 @default.
• W2024301095 hasConceptScore W2024301095C104317684 @default.

• next