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- W2024302110 abstract "Abstract Heparin-S 35 was injected into dogs, and the properties of the radioactive material excreted in the urine were studied. It was found that after administration of small doses, all the label is excreted as inorganic sulfate. On the other hand, after injection of larger amounts the urine contains an appreciable portion of the S 35 associated with heparin and other mucopolysaccharide material. It is concluded that as a result of metabolic degradation the sulfate linkages of heparin are cleaved. However, the capability of the animal to perform this hydrolysis is limited so that when excessive amounts are administered, a significant portion is excreted unchanged or only partially desulfated." @default.
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- W2024302110 date "1959-11-01" @default.
- W2024302110 modified "2023-09-27" @default.
- W2024302110 title "Studies on the metabolism of heparin" @default.
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- W2024302110 doi "https://doi.org/10.1016/0003-9861(59)90446-1" @default.
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