FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024303172> ?p ?o ?g. }

• W2024303172 endingPage "4355" @default.
• W2024303172 startingPage "4348" @default.
• W2024303172 abstract "A novel amphiphilic and cationic triblock copolymer consisting of monomethoxy poly(ethylene glycol), poly(ɛ-caprolactone) (PCL) and poly(2-aminoethyl ethylene phosphate) denoted as mPEG45-b-PCL100-b-PPEEA12 was designed and synthesized for siRNA delivery. The copolymers were well characterized by 1H NMR spectroscopy and gel permeation chromatography. Micelle nanoparticles' (MNPs) formation of this amphiphilic copolymer in aqueous solution was studied by dynamic light scattering, transmission electron microscopy and fluorescence technique. MNPs took uniform spherical morphology with zeta potential of around 45 mV and were stabilized by hydrophobic–hydrophobic interaction in the PCL core, exhibiting the critical micelle concentration at 2.7 × 10−3 mg/mL. Such MNPs allowed siRNA loading post nanoparticle formation without change in uniformity. The average diameter of nanoparticles after siRNA binding ranged from 98 to 125 nm depending on N/P ratios. The siRNA loaded nanoparticles can be effectively internalized and subsequently release siRNA in HEK293 cells, resulting in significant gene knockdown activities, which was demonstrated by delivering two siRNAs targeting green fluorescence protein (GFP). It effectively silenced GFP expression in 40–70% GFP-expressed HEK293 cells and it was observed that higher N/P ratio resulted in more effective silence which was likely due to better cell internalization at higher N/P ratio. MTT assay demonstrated that neither MNPs themselves nor siRNA loaded MNPs showed cytotoxicity even at high concentrations. Such cationic MNPs made from biocompatible and biodegradable polymers are promising for siRNA delivery." @default.
• W2024303172 created "2016-06-24" @default.
• W2024303172 creator A5006923608 @default.
• W2024303172 creator A5023294622 @default.
• W2024303172 creator A5041932563 @default.
• W2024303172 creator A5067819419 @default.
• W2024303172 creator A5079785653 @default.
• W2024303172 date "2008-11-01" @default.
• W2024303172 modified "2023-10-14" @default.
• W2024303172 title "Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery" @default.
• W2024303172 cites W1568037090 @default.
• W2024303172 cites W1662084969 @default.
• W2024303172 cites W1969383121 @default.
• W2024303172 cites W1971697641 @default.
• W2024303172 cites W1973350289 @default.
• W2024303172 cites W1984568212 @default.
• W2024303172 cites W1989611595 @default.
• W2024303172 cites W1999284097 @default.
• W2024303172 cites W2008565129 @default.
• W2024303172 cites W2012395572 @default.
• W2024303172 cites W2012821120 @default.
• W2024303172 cites W2016156919 @default.
• W2024303172 cites W2019631541 @default.
• W2024303172 cites W2021905258 @default.
• W2024303172 cites W2026483148 @default.
• W2024303172 cites W2028893730 @default.
• W2024303172 cites W2030833955 @default.
• W2024303172 cites W2032028101 @default.
• W2024303172 cites W2042740307 @default.
• W2024303172 cites W2047165821 @default.
• W2024303172 cites W2054185238 @default.
• W2024303172 cites W2056311063 @default.
• W2024303172 cites W2057848113 @default.
• W2024303172 cites W2060056553 @default.
• W2024303172 cites W2066299908 @default.
• W2024303172 cites W2066919995 @default.
• W2024303172 cites W2073381065 @default.
• W2024303172 cites W2073725948 @default.
• W2024303172 cites W2079017926 @default.
• W2024303172 cites W2082587127 @default.
• W2024303172 cites W2083144709 @default.
• W2024303172 cites W2083960630 @default.
• W2024303172 cites W2095151181 @default.
• W2024303172 cites W2096671921 @default.
• W2024303172 cites W2104558356 @default.
• W2024303172 cites W2116424844 @default.
• W2024303172 cites W2118143190 @default.
• W2024303172 cites W2118366787 @default.
• W2024303172 cites W2119457682 @default.
• W2024303172 cites W2123175900 @default.
• W2024303172 cites W2124018243 @default.
• W2024303172 cites W2127667644 @default.
• W2024303172 cites W2138436760 @default.
• W2024303172 cites W2151760476 @default.
• W2024303172 cites W2160029095 @default.
• W2024303172 cites W2165243439 @default.
• W2024303172 cites W2166915947 @default.
• W2024303172 cites W2320450560 @default.
• W2024303172 cites W4213363263 @default.
• W2024303172 doi "https://doi.org/10.1016/j.biomaterials.2008.07.036" @default.
• W2024303172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18715636" @default.
• W2024303172 hasPublicationYear "2008" @default.
• W2024303172 type Work @default.
• W2024303172 sameAs 2024303172 @default.
• W2024303172 citedByCount "228" @default.
• W2024303172 countsByYear W20243031722012 @default.
• W2024303172 countsByYear W20243031722013 @default.
• W2024303172 countsByYear W20243031722014 @default.
• W2024303172 countsByYear W20243031722015 @default.
• W2024303172 countsByYear W20243031722016 @default.
• W2024303172 countsByYear W20243031722017 @default.
• W2024303172 countsByYear W20243031722018 @default.
• W2024303172 countsByYear W20243031722019 @default.
• W2024303172 countsByYear W20243031722020 @default.
• W2024303172 countsByYear W20243031722021 @default.
• W2024303172 countsByYear W20243031722022 @default.
• W2024303172 countsByYear W20243031722023 @default.
• W2024303172 crossrefType "journal-article" @default.
• W2024303172 hasAuthorship W2024303172A5006923608 @default.
• W2024303172 hasAuthorship W2024303172A5023294622 @default.
• W2024303172 hasAuthorship W2024303172A5041932563 @default.
• W2024303172 hasAuthorship W2024303172A5067819419 @default.
• W2024303172 hasAuthorship W2024303172A5079785653 @default.
• W2024303172 hasConcept C11268172 @default.
• W2024303172 hasConcept C12554922 @default.
• W2024303172 hasConcept C127413603 @default.
• W2024303172 hasConcept C13965031 @default.
• W2024303172 hasConcept C14631669 @default.
• W2024303172 hasConcept C155672457 @default.
• W2024303172 hasConcept C15920480 @default.
• W2024303172 hasConcept C159985019 @default.
• W2024303172 hasConcept C171250308 @default.
• W2024303172 hasConcept C178790620 @default.
• W2024303172 hasConcept C183882617 @default.
• W2024303172 hasConcept C184651966 @default.
• W2024303172 hasConcept C185592680 @default.
• W2024303172 hasConcept C188027245 @default.
• W2024303172 hasConcept C192562407 @default.

• next