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- W2024303872 endingPage "424" @default.
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- W2024303872 abstract "Toll-like receptor (TLR) signaling leads to the activation of mitogen-activated protein kinase and nuclear factor-κB signaling pathways. While the upstream signaling events initiated at the level of adaptors and the activation of the downstream signaling pathways have received a lot of attention, our understanding of how these signaling pathways are coordinated to regulate gene expression is poorly understood. This review gives a selective overview on our current understanding of signaling downstream of TLRs, with an emphasis on how the upstream kinases like the mitogen-activated protein kinase kinase kinases (TAK1 and Tpl2) and inhibitor of κ-B kinase (IKK) coordinate the signaling events that steer the course of an immune response." @default.
- W2024303872 created "2016-06-24" @default.
- W2024303872 creator A5010484968 @default.
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- W2024303872 date "2007-07-17" @default.
- W2024303872 modified "2023-09-24" @default.
- W2024303872 title "Coordinating TLR‐activated signaling pathways in cells of the immune system" @default.
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- W2024303872 doi "https://doi.org/10.1038/sj.icb.7100098" @default.
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