FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024305817> ?p ?o ?g. }

• W2024305817 endingPage "H988" @default.
• W2024305817 startingPage "H979" @default.
• W2024305817 abstract "Expression of GSK-3α is increased in aging hearts and those subjected to hemodynamic overload. Overexpressed GSK-3α inhibits ERK and enhances pressure overload (PO)-induced cardiac dysfunction. We studied whether suppression of the MEK1/ERK pathway contributes to cardiac responses induced by overexpressed GSK-3α using constitutively active MEK1 (CA-MEK1)/GSK-3α bigenic mice (bigenic mice), which were obtained by crossing cardiac-specific GSK-3α transgenic mice (Tg-GSK) and cardiac-specific CA-MEK1 transgenic mice (Tg-MEK1). The suppression of ERK phosphorylation observed in Tg-GSK was eliminated in bigenic mice. At 12 mo, left ventricular (LV) weight/tibia length, LV weight/body weight, and cardiac myocyte size were significantly smaller in Tg-GSK than in nontransgenic mice (NTg), but were not significantly different between Tg-MEK1 and bigenic mice. The LV ejection fraction (LVEF), fractional shortening (FS), and change in pressure over time were significantly lower in Tg-GSK than in NTg, but were not significantly different between bigenic mice and Tg-MEK1. The increase in apoptosis in Tg-GSK was abolished in bigenic mice, although the increase in fibrosis was not. After PO, the decrease in cardiac hypertrophy and the enhancement of apoptosis seen in Tg-GSK were abrogated in bigenic mice. After PO, the LVEF and FS were significantly reduced in Tg-GSK compared with its sham, but not in NTg, Tg-MEK1, or bigenic mice compared with their respective shams. There was no significant difference in LVEF and FS between bigenic mice and Tg-MEK1 after PO. In conclusion, inhibition of the MEK1/ERK pathway mediates the hypertrophy suppression and cardiac dysfunction caused by GSK-3α overexpression in cardiac myocytes." @default.
• W2024305817 created "2016-06-24" @default.
• W2024305817 creator A5002791625 @default.
• W2024305817 creator A5009804689 @default.
• W2024305817 creator A5044383005 @default.
• W2024305817 creator A5075550603 @default.
• W2024305817 creator A5091471046 @default.
• W2024305817 date "2012-10-15" @default.
• W2024305817 modified "2023-10-18" @default.
• W2024305817 title "Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload" @default.
• W2024305817 cites W1972343960 @default.
• W2024305817 cites W1983066278 @default.
• W2024305817 cites W2000121002 @default.
• W2024305817 cites W2008421466 @default.
• W2024305817 cites W2012448969 @default.
• W2024305817 cites W2013880106 @default.
• W2024305817 cites W2015615030 @default.
• W2024305817 cites W2016596969 @default.
• W2024305817 cites W2022779304 @default.
• W2024305817 cites W2031233485 @default.
• W2024305817 cites W2048660144 @default.
• W2024305817 cites W2057994513 @default.
• W2024305817 cites W2079131177 @default.
• W2024305817 cites W2087706354 @default.
• W2024305817 cites W2088658807 @default.
• W2024305817 cites W2104987037 @default.
• W2024305817 cites W2105014609 @default.
• W2024305817 cites W2108083474 @default.
• W2024305817 cites W2111478093 @default.
• W2024305817 cites W2113017041 @default.
• W2024305817 cites W2113788146 @default.
• W2024305817 cites W2117272570 @default.
• W2024305817 cites W2118221757 @default.
• W2024305817 cites W2126012511 @default.
• W2024305817 cites W2130143704 @default.
• W2024305817 cites W2137909108 @default.
• W2024305817 cites W2139855640 @default.
• W2024305817 cites W2140608810 @default.
• W2024305817 cites W2143577214 @default.
• W2024305817 cites W2155591792 @default.
• W2024305817 cites W2155721504 @default.
• W2024305817 cites W2341478304 @default.
• W2024305817 cites W4245365571 @default.
• W2024305817 cites W4256264762 @default.
• W2024305817 doi "https://doi.org/10.1152/ajpheart.00415.2012" @default.
• W2024305817 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3774208" @default.
• W2024305817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22904158" @default.
• W2024305817 hasPublicationYear "2012" @default.
• W2024305817 type Work @default.
• W2024305817 sameAs 2024305817 @default.
• W2024305817 citedByCount "18" @default.
• W2024305817 countsByYear W20243058172014 @default.
• W2024305817 countsByYear W20243058172015 @default.
• W2024305817 countsByYear W20243058172016 @default.
• W2024305817 countsByYear W20243058172018 @default.
• W2024305817 countsByYear W20243058172020 @default.
• W2024305817 countsByYear W20243058172021 @default.
• W2024305817 countsByYear W20243058172022 @default.
• W2024305817 countsByYear W20243058172023 @default.
• W2024305817 crossrefType "journal-article" @default.
• W2024305817 hasAuthorship W2024305817A5002791625 @default.
• W2024305817 hasAuthorship W2024305817A5009804689 @default.
• W2024305817 hasAuthorship W2024305817A5044383005 @default.
• W2024305817 hasAuthorship W2024305817A5075550603 @default.
• W2024305817 hasAuthorship W2024305817A5091471046 @default.
• W2024305817 hasBestOaLocation W20243058172 @default.
• W2024305817 hasConcept C11960822 @default.
• W2024305817 hasConcept C126322002 @default.
• W2024305817 hasConcept C134018914 @default.
• W2024305817 hasConcept C167414201 @default.
• W2024305817 hasConcept C178853913 @default.
• W2024305817 hasConcept C182996813 @default.
• W2024305817 hasConcept C185592680 @default.
• W2024305817 hasConcept C190283241 @default.
• W2024305817 hasConcept C2778271984 @default.
• W2024305817 hasConcept C2779676291 @default.
• W2024305817 hasConcept C3018791406 @default.
• W2024305817 hasConcept C500558357 @default.
• W2024305817 hasConcept C55493867 @default.
• W2024305817 hasConcept C57074206 @default.
• W2024305817 hasConcept C71924100 @default.
• W2024305817 hasConceptScore W2024305817C11960822 @default.
• W2024305817 hasConceptScore W2024305817C126322002 @default.
• W2024305817 hasConceptScore W2024305817C134018914 @default.
• W2024305817 hasConceptScore W2024305817C167414201 @default.
• W2024305817 hasConceptScore W2024305817C178853913 @default.
• W2024305817 hasConceptScore W2024305817C182996813 @default.
• W2024305817 hasConceptScore W2024305817C185592680 @default.
• W2024305817 hasConceptScore W2024305817C190283241 @default.
• W2024305817 hasConceptScore W2024305817C2778271984 @default.
• W2024305817 hasConceptScore W2024305817C2779676291 @default.
• W2024305817 hasConceptScore W2024305817C3018791406 @default.
• W2024305817 hasConceptScore W2024305817C500558357 @default.
• W2024305817 hasConceptScore W2024305817C55493867 @default.
• W2024305817 hasConceptScore W2024305817C57074206 @default.
• W2024305817 hasConceptScore W2024305817C71924100 @default.
• W2024305817 hasIssue "8" @default.
• W2024305817 hasLocation W20243058171 @default.

• next