FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024308369> ?p ?o ?g. }

• W2024308369 endingPage "6488" @default.
• W2024308369 startingPage "6479" @default.
• W2024308369 abstract "Type XIV collagen, a fibril-associated collagen with interrupted triple helices (FACIT), interacts with the surrounding extracellular matrix and/or with cells via its binding to glycosaminoglycans (GAGs). To further characterize such interactions in the NC1 domain of chicken collagen XIV, we identified amino acids essential for heparin binding by affinity chromatography analysis after proteolytic digestion of the synthetic peptide NC1(84-116). The 3D structure of this peptide was then obtained using circular dichroism and NMR. The NC1(84-116) peptide appeared poorly structured in water, but the stabilization of its conformation by the interaction with hydrophobic surfaces or by using cosolvents (TFE, SDS) revealed a high propensity to adopt an alpha-helical folding. A 3D structure model of NC1(84-116), calculated from NMR data recorded in a TFE/water mixture, showed that the NC1-heparin binding site forms a amphipathic alpha-helix exhibiting a twisted basic groove. It is structurally similar to the consensus spatial alpha-helix model of heparin-binding [Margalit et al. (1993) J. Biol. Chem. 268, 19228-19231], except that the GAG binding domain of NC1 may be extended over 18 residues, that is, the NC1(94-111) segment. In addition, the formation of a hydrophobic groove upon helix formation suggests the contribution of additional sequences to ensure the stability of the GAG-binding domain. Overall the NC1(84-116) model exhibits a nativelike conformation which presents suitably oriented residues for the interaction with a specific GAG." @default.
• W2024308369 created "2016-06-24" @default.
• W2024308369 creator A5009109452 @default.
• W2024308369 creator A5024512675 @default.
• W2024308369 creator A5030252277 @default.
• W2024308369 creator A5031681383 @default.
• W2024308369 creator A5037871126 @default.
• W2024308369 creator A5050142545 @default.
• W2024308369 creator A5064673349 @default.
• W2024308369 creator A5080892506 @default.
• W2024308369 creator A5085042381 @default.
• W2024308369 date "1999-04-29" @default.
• W2024308369 modified "2023-09-25" @default.
• W2024308369 title "Structural Analysis of the Heparin-Binding Site of the NC1 Domain of Collagen XIV by CD and NMR^," @default.
• W2024308369 cites W1579619270 @default.
• W2024308369 cites W1591638778 @default.
• W2024308369 cites W1596750278 @default.
• W2024308369 cites W1959440999 @default.
• W2024308369 cites W1965117601 @default.
• W2024308369 cites W1965156062 @default.
• W2024308369 cites W1968302214 @default.
• W2024308369 cites W1980205281 @default.
• W2024308369 cites W1986191025 @default.
• W2024308369 cites W1998766565 @default.
• W2024308369 cites W1999214538 @default.
• W2024308369 cites W2008707480 @default.
• W2024308369 cites W2012941916 @default.
• W2024308369 cites W2013965701 @default.
• W2024308369 cites W2032359510 @default.
• W2024308369 cites W2034898690 @default.
• W2024308369 cites W2040168475 @default.
• W2024308369 cites W2045674145 @default.
• W2024308369 cites W2067068561 @default.
• W2024308369 cites W2074267151 @default.
• W2024308369 cites W2077460527 @default.
• W2024308369 cites W2078709265 @default.
• W2024308369 cites W2090035199 @default.
• W2024308369 cites W2092751827 @default.
• W2024308369 cites W2097707959 @default.
• W2024308369 cites W2107876005 @default.
• W2024308369 cites W2144985870 @default.
• W2024308369 cites W2148521301 @default.
• W2024308369 cites W2151236213 @default.
• W2024308369 cites W2289101943 @default.
• W2024308369 cites W2949250147 @default.
• W2024308369 cites W34966227 @default.
• W2024308369 cites W4233269677 @default.
• W2024308369 doi "https://doi.org/10.1021/bi9900222" @default.
• W2024308369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10350466" @default.
• W2024308369 hasPublicationYear "1999" @default.
• W2024308369 type Work @default.
• W2024308369 sameAs 2024308369 @default.
• W2024308369 citedByCount "31" @default.
• W2024308369 countsByYear W20243083692012 @default.
• W2024308369 countsByYear W20243083692013 @default.
• W2024308369 countsByYear W20243083692014 @default.
• W2024308369 countsByYear W20243083692017 @default.
• W2024308369 countsByYear W20243083692018 @default.
• W2024308369 crossrefType "journal-article" @default.
• W2024308369 hasAuthorship W2024308369A5009109452 @default.
• W2024308369 hasAuthorship W2024308369A5024512675 @default.
• W2024308369 hasAuthorship W2024308369A5030252277 @default.
• W2024308369 hasAuthorship W2024308369A5031681383 @default.
• W2024308369 hasAuthorship W2024308369A5037871126 @default.
• W2024308369 hasAuthorship W2024308369A5050142545 @default.
• W2024308369 hasAuthorship W2024308369A5064673349 @default.
• W2024308369 hasAuthorship W2024308369A5080892506 @default.
• W2024308369 hasAuthorship W2024308369A5085042381 @default.
• W2024308369 hasConcept C107824862 @default.
• W2024308369 hasConcept C10919887 @default.
• W2024308369 hasConcept C119599485 @default.
• W2024308369 hasConcept C12554922 @default.
• W2024308369 hasConcept C127413603 @default.
• W2024308369 hasConcept C133571119 @default.
• W2024308369 hasConcept C153074725 @default.
• W2024308369 hasConcept C155181932 @default.
• W2024308369 hasConcept C185592680 @default.
• W2024308369 hasConcept C18903297 @default.
• W2024308369 hasConcept C2776545253 @default.
• W2024308369 hasConcept C2778530040 @default.
• W2024308369 hasConcept C2779281246 @default.
• W2024308369 hasConcept C2779965526 @default.
• W2024308369 hasConcept C55493867 @default.
• W2024308369 hasConcept C66974803 @default.
• W2024308369 hasConcept C71240020 @default.
• W2024308369 hasConcept C86803240 @default.
• W2024308369 hasConceptScore W2024308369C107824862 @default.
• W2024308369 hasConceptScore W2024308369C10919887 @default.
• W2024308369 hasConceptScore W2024308369C119599485 @default.
• W2024308369 hasConceptScore W2024308369C12554922 @default.
• W2024308369 hasConceptScore W2024308369C127413603 @default.
• W2024308369 hasConceptScore W2024308369C133571119 @default.
• W2024308369 hasConceptScore W2024308369C153074725 @default.
• W2024308369 hasConceptScore W2024308369C155181932 @default.
• W2024308369 hasConceptScore W2024308369C185592680 @default.
• W2024308369 hasConceptScore W2024308369C18903297 @default.
• W2024308369 hasConceptScore W2024308369C2776545253 @default.
• W2024308369 hasConceptScore W2024308369C2778530040 @default.

• next