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- W2024309415 abstract "The expression of the gene encoding herpes simplex virus thymidine kinase (HSV-TK) in eukaryotic cells confers sensitivity to antiherpetic drugs such as acyclovir and ganciclovir. This property has been proposed for use in gene therapy approaches to kill either cancer cells or HIV-infected cells. Several animal experiments have shown the regression of tumors after in vivo transfer of the HSV-TK gene followed by ganciclovir treatment. Furthermore, CD4+T cells harboring the HSV-TK gene under the control of HIV regulatory sequences are protected from HIV spreading in the presence of acyclovir. Thus, the HSV-TK gene has potential applications in gene therapy for the treatment of cancer and HIV infection." @default.
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- W2024309415 date "1996-05-01" @default.
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- W2024309415 title "Gene therapy against cancer and HIV infection using the gene encoding herpes simplex virus thymidine kinase" @default.
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- W2024309415 doi "https://doi.org/10.1016/1357-4310(96)88774-0" @default.
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