FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024321027> ?p ?o ?g. }

• W2024321027 endingPage "e56744" @default.
• W2024321027 startingPage "e56744" @default.
• W2024321027 abstract "Cutaneous ATP release plays an important role in both epidermal stratification and chronic pain, but little is known about ATP release mechanisms in keratinocytes that comprise the epidermis. In this study, we analyzed ATP release from cultured human neonatal keratinocytes briefly exposed to air, a process previously demonstrated to trigger ATP release from these cells. We show that exposing keratinocytes to air by removing media for 15 seconds causes a robust, long-lasting ATP release. This air-stimulated ATP release was increased in calcium differentiated cultures which showed a corresponding increase in connexin 43 mRNA, a major component of keratinocyte hemichannels. The known connexin hemichannel inhibitors 1-octanol and carbenoxolone both significantly reduced air-stimulated ATP release, as did two drugs traditionally used as ABC transporter inhibitors (glibenclamide and verapamil). These same 4 inhibitors also prevented an increase in the uptake of a connexin permeable dye induced by air exposure, confirming that connexin hemichannels are open during air-stimulated ATP release. In contrast, activity of the MDR1 ABC transporter was reduced by air exposure and the drugs that inhibited air-stimulated ATP release had differential effects on this transporter. These results indicate that air exposure elicits non-vesicular release of ATP from keratinocytes through connexin hemichannels and that drugs used to target connexin hemichannels and ABC transporters may cross-inhibit. Connexins represent a novel, peripheral target for the treatment of chronic pain and dermatological disease." @default.
• W2024321027 created "2016-06-24" @default.
• W2024321027 creator A5003639146 @default.
• W2024321027 creator A5028335058 @default.
• W2024321027 creator A5039485353 @default.
• W2024321027 creator A5065822870 @default.
• W2024321027 creator A5077395570 @default.
• W2024321027 creator A5080160063 @default.
• W2024321027 date "2013-02-15" @default.
• W2024321027 modified "2023-10-01" @default.
• W2024321027 title "Air-Stimulated ATP Release from Keratinocytes Occurs through Connexin Hemichannels" @default.
• W2024321027 cites W133811466 @default.
• W2024321027 cites W1558564171 @default.
• W2024321027 cites W1573567421 @default.
• W2024321027 cites W1697474905 @default.
• W2024321027 cites W1890304486 @default.
• W2024321027 cites W1963792755 @default.
• W2024321027 cites W1973036355 @default.
• W2024321027 cites W1975937980 @default.
• W2024321027 cites W1980145058 @default.
• W2024321027 cites W1985254199 @default.
• W2024321027 cites W1985703062 @default.
• W2024321027 cites W1987580294 @default.
• W2024321027 cites W1989149160 @default.
• W2024321027 cites W1989265269 @default.
• W2024321027 cites W1992772441 @default.
• W2024321027 cites W1999391879 @default.
• W2024321027 cites W2001883295 @default.
• W2024321027 cites W2002540929 @default.
• W2024321027 cites W2005092240 @default.
• W2024321027 cites W2013278446 @default.
• W2024321027 cites W2014320592 @default.
• W2024321027 cites W2015395924 @default.
• W2024321027 cites W2020021115 @default.
• W2024321027 cites W2020831130 @default.
• W2024321027 cites W2021116858 @default.
• W2024321027 cites W2027981901 @default.
• W2024321027 cites W2028304504 @default.
• W2024321027 cites W2028899000 @default.
• W2024321027 cites W2029261091 @default.
• W2024321027 cites W2037011908 @default.
• W2024321027 cites W2039106853 @default.
• W2024321027 cites W2039129821 @default.
• W2024321027 cites W2043373262 @default.
• W2024321027 cites W2050725524 @default.
• W2024321027 cites W2055866154 @default.
• W2024321027 cites W2064186269 @default.
• W2024321027 cites W2064376284 @default.
• W2024321027 cites W2066158055 @default.
• W2024321027 cites W2069087512 @default.
• W2024321027 cites W2073451266 @default.
• W2024321027 cites W2074027763 @default.
• W2024321027 cites W2078031031 @default.
• W2024321027 cites W2078610923 @default.
• W2024321027 cites W2086035859 @default.
• W2024321027 cites W2086488050 @default.
• W2024321027 cites W2087172186 @default.
• W2024321027 cites W2090755555 @default.
• W2024321027 cites W2101484677 @default.
• W2024321027 cites W2106753138 @default.
• W2024321027 cites W2106799985 @default.
• W2024321027 cites W2117781731 @default.
• W2024321027 cites W2124017577 @default.
• W2024321027 cites W2129561558 @default.
• W2024321027 cites W2130372379 @default.
• W2024321027 cites W2130430718 @default.
• W2024321027 cites W2138599948 @default.
• W2024321027 cites W2141180468 @default.
• W2024321027 cites W2143347281 @default.
• W2024321027 cites W2157577807 @default.
• W2024321027 cites W2160876060 @default.
• W2024321027 cites W2167719316 @default.
• W2024321027 doi "https://doi.org/10.1371/journal.pone.0056744" @default.
• W2024321027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3574084" @default.
• W2024321027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23457608" @default.
• W2024321027 hasPublicationYear "2013" @default.
• W2024321027 type Work @default.
• W2024321027 sameAs 2024321027 @default.
• W2024321027 citedByCount "46" @default.
• W2024321027 countsByYear W20243210272013 @default.
• W2024321027 countsByYear W20243210272014 @default.
• W2024321027 countsByYear W20243210272015 @default.
• W2024321027 countsByYear W20243210272016 @default.
• W2024321027 countsByYear W20243210272017 @default.
• W2024321027 countsByYear W20243210272018 @default.
• W2024321027 countsByYear W20243210272019 @default.
• W2024321027 countsByYear W20243210272020 @default.
• W2024321027 countsByYear W20243210272021 @default.
• W2024321027 countsByYear W20243210272022 @default.
• W2024321027 countsByYear W20243210272023 @default.
• W2024321027 crossrefType "journal-article" @default.
• W2024321027 hasAuthorship W2024321027A5003639146 @default.
• W2024321027 hasAuthorship W2024321027A5028335058 @default.
• W2024321027 hasAuthorship W2024321027A5039485353 @default.
• W2024321027 hasAuthorship W2024321027A5065822870 @default.
• W2024321027 hasAuthorship W2024321027A5077395570 @default.
• W2024321027 hasAuthorship W2024321027A5080160063 @default.
• W2024321027 hasBestOaLocation W20243210271 @default.

• next