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- W2024321824 startingPage "162" @default.
- W2024321824 abstract "C1q, the first subcomponent of the classical pathway, is a charge pattern recognition molecule that binds a diverse range of self, non-self and altered self ligands, leading to pro-inflammatory complement activation. Although complement is required for tissue homeostasis as well as defence against pathogens, exaggerated complement activation can be damaging to the tissue. Therefore, a fine balance between complement activation and inhibition is necessary. We have recently found that factor H, a polyanion recognition molecule and soluble regulator of alternative pathway activation in blood and on cell surfaces, can directly compete with C1q in binding to anionic phospholipids (cardiolipin), lipid A and Escherichia coli (three known activators of the classical pathway) and acts as a direct down regulator of the complement classical pathway. This ability of factor H to dampen classical pathway activation is distinct from its role as an alternative pathway down-regulator. Thus, by directly competing for specific C1q ligands (exogenous as well as endogenous), factor H is likely to be involved in fine-tuning and balancing the C1q-driven inflammatory processes in autoimmunity and infection. However, in the case of apoptotic cells, C1q-mediated enhancement of uptake/adhesion of the apoptotic cells by monocytes was reduced by factor H. Thus, factor H may be important in controlling the inflammation, which might arise from C1q deposition on apoptotic cells." @default.
- W2024321824 created "2016-06-24" @default.
- W2024321824 creator A5045570551 @default.
- W2024321824 creator A5056841601 @default.
- W2024321824 date "2012-02-01" @default.
- W2024321824 modified "2023-09-25" @default.
- W2024321824 title "Factor H as a regulator of the classical pathway activation" @default.
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- W2024321824 doi "https://doi.org/10.1016/j.imbio.2011.07.024" @default.
- W2024321824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21852018" @default.
- W2024321824 hasPublicationYear "2012" @default.