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- W2024322851 abstract "We performed different in vivo investigations to study the pharmacological properties of a native DS: anti-thrombosis by the stasis model, bleeding potential by tail transection bleeding time and template bleeding time, and profibrinolysis by a growing thrombus model and by an established thrombus model. The results suggest that DS is a safe antithrombotic drug by i.v. administration without bleeding potential, even at very high doses (up to 16 mg/Kg). DS has shown a protective index of at least 4 in contrast to heparin that has shown a protective index of 1. The profibrinolytic models so far studied did not evidence a clear profibrinolytic contribution to the antithrombotic properties of DS, but showed a prolonged antithrombotic action that cannot be explained only by the heparin cofactor II potentiation." @default.
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- W2024322851 date "1992-07-01" @default.
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- W2024322851 title "Pharmacological profile of a native dermatan sulfate" @default.
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- W2024322851 doi "https://doi.org/10.1016/0049-3848(92)90139-2" @default.
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