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• W2024328265 abstract "Thyrotropin releasing hormone (TRH) accelerates the turnover of phosphatidylinositol in GH3 cells ('phospholipid response'). From the analysis of inositol phosphates in the presence of Li+ which inhibits their dephosphorylation, it can be concluded that the hydrolysis of phosphatidylinositol 4,5-biphosphate, and possibly of phosphatidylinositol 4-phosphate by phospholipase C is markedly accelerated by TRH. It appears that this reaction initiates the acceleration of phosphatidylinositol turnover. The specificity of hormonally regulated phospholipase C reaction for polyphosphoinositides has important implications for the potential role of the phospholipid response as a mechanism of membrane signal transduction." @default.
• W2024328265 created "2016-06-24" @default.
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• W2024328265 date "1984-03-12" @default.
• W2024328265 modified "2023-09-26" @default.
• W2024328265 title "Polyphosphoinositide hydrolysis by phospholipase C is accelerated by thyrotropin releasing hormone (TRH) in clonal rat pituitary cells (GH₃ cells)" @default.
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• W2024328265 doi "https://doi.org/10.1016/0014-5793(84)80205-7" @default.
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