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• W2024331268 endingPage "1573" @default.
• W2024331268 startingPage "1565" @default.
• W2024331268 abstract "Ascorbate levels decrease in organisms subjected to oxidative stress, but the responsible reactions have not been identified. Our earlier studies have shown that protein C-centered radicals react rapidly with ascorbate. In aerobes, these radicals can react with oxygen to form peroxyl radicals. To estimate the relative probabilities of the reactions of ascorbate with protein C- and O-centered radicals, we measured by pulse radiolysis the rate constants of the reactions of C-centered radicals in Gly, Ala, and Pro with O₂ and of the resultant peroxyl radicals with ascorbate. Calculations based on the concentrations of ascorbate and oxygen in human tissues show that the relative probabilities of reactions of the C-centered amino acid radicals with O₂ and ascorbate vary between 1:2.6 for the pituitary gland and 1:0.02 for plasma, with intermediate ratios for other tissues. The high frequency of occurrence of Gly, Ala, and Pro in proteins and the similar reaction rate constants of their C-centered radicals with O₂ and their peroxo-radicals with ascorbate suggest that our results are also valid for proteins. Thus, the formation of protein C- or O-centered radicals in vivo can account for the loss of ascorbate in organisms under oxidative stress." @default.
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• W2024331268 date "2012-10-01" @default.
• W2024331268 modified "2023-10-03" @default.
• W2024331268 title "Efficient depletion of ascorbate by amino acid and protein radicals under oxidative stress" @default.
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• W2024331268 doi "https://doi.org/10.1016/j.freeradbiomed.2012.08.005" @default.
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