FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024331999> ?p ?o ?g. }

• W2024331999 endingPage "717" @default.
• W2024331999 startingPage "708" @default.
• W2024331999 abstract "Oral insulin therapy has great potential benefits over conventional therapy for diabetic patients as well as mimicking the physiological fate of insulin. Here we evaluated the characteristics of insulin and deoxycholate-based synthetic Nα-deoxycholyl-l-lysyl-methylester (DCK) complex, and diabetes correction in pancreatectomized canines after oral administration. After the insulin/DCK complexation was made, the insulin’s folding structure, stability against digestive enzymes, lipophilicity and permeability to Caco-2 monolayer were evaluated in vitro. Diabetic canines were kept under fasting conditions, and Eudragit-coated gelatin capsules containing insulin or insulin/DCK powder were singly or triply administered. Evaluation of glucodynamics, pharmacokinetics, oral glucose tolerance test (OGTT) and reproducibility were carried out. After complexation with DCK, the folding structure of insulin did not become denatured and the resistance against digestive enzymes was powerfully improved. The lipophilicity and permeability of insulin/DCK (coupling ratio up to 1:10) were also highly increased. The insulin/DCK complex, administered orally into diabetic canines at the doses of 21, 42, and 81 IU/kg, reduced the plasma glucose levels by about 28%, 44% and 67%, respectively, while the plasma insulin concentrations increased. During OGTT, insulin/DCK nearly maintained the normoglycemic state in the diabetic canines, whereas the hyperglycemic state of placebo-treated controls was not corrected. During oral administration of insulin/DCK, it repetitively showed similar therapeutic efficacy in diabetic canines for 3 days. The therapeutic efficacy of insulin/DCK was exhibited in its digestive enzyme resistance, deoxycholate-based lipophilicity for enhancing permeability and intact insulin delivery without chemical modification, providing potential oral therapeutic remedy as an alternative to injectable insulin medication." @default.
• W2024331999 created "2016-06-24" @default.
• W2024331999 creator A5002495281 @default.
• W2024331999 creator A5028983150 @default.
• W2024331999 creator A5032796168 @default.
• W2024331999 creator A5037650113 @default.
• W2024331999 creator A5042365463 @default.
• W2024331999 creator A5072689710 @default.
• W2024331999 creator A5057313891 @default.
• W2024331999 date "2010-05-03" @default.
• W2024331999 modified "2023-09-29" @default.
• W2024331999 title "Diabetes Correction in Pancreatectomized Canines by Orally Absorbable Insulin−Deoxycholate Complex" @default.
• W2024331999 cites W1593135300 @default.
• W2024331999 cites W170914365 @default.
• W2024331999 cites W1965884363 @default.
• W2024331999 cites W1967147106 @default.
• W2024331999 cites W1975230408 @default.
• W2024331999 cites W1981002646 @default.
• W2024331999 cites W1983366975 @default.
• W2024331999 cites W2019765848 @default.
• W2024331999 cites W2024703515 @default.
• W2024331999 cites W2026505267 @default.
• W2024331999 cites W2036100809 @default.
• W2024331999 cites W2037758064 @default.
• W2024331999 cites W2046586249 @default.
• W2024331999 cites W2047183738 @default.
• W2024331999 cites W2047796161 @default.
• W2024331999 cites W2062690180 @default.
• W2024331999 cites W2064289043 @default.
• W2024331999 cites W2068601883 @default.
• W2024331999 cites W2071590632 @default.
• W2024331999 cites W2072036731 @default.
• W2024331999 cites W2072838944 @default.
• W2024331999 cites W2089895673 @default.
• W2024331999 cites W2098731905 @default.
• W2024331999 cites W2107178752 @default.
• W2024331999 cites W2115032517 @default.
• W2024331999 cites W2118784523 @default.
• W2024331999 cites W2119063869 @default.
• W2024331999 cites W2124473241 @default.
• W2024331999 cites W2127655091 @default.
• W2024331999 cites W2139729210 @default.
• W2024331999 cites W3099920771 @default.
• W2024331999 cites W4301950188 @default.
• W2024331999 doi "https://doi.org/10.1021/mp9002688" @default.
• W2024331999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20361761" @default.
• W2024331999 hasPublicationYear "2010" @default.
• W2024331999 type Work @default.
• W2024331999 sameAs 2024331999 @default.
• W2024331999 citedByCount "22" @default.
• W2024331999 countsByYear W20243319992012 @default.
• W2024331999 countsByYear W20243319992013 @default.
• W2024331999 countsByYear W20243319992014 @default.
• W2024331999 countsByYear W20243319992015 @default.
• W2024331999 countsByYear W20243319992016 @default.
• W2024331999 countsByYear W20243319992017 @default.
• W2024331999 countsByYear W20243319992018 @default.
• W2024331999 countsByYear W20243319992019 @default.
• W2024331999 countsByYear W20243319992022 @default.
• W2024331999 crossrefType "journal-article" @default.
• W2024331999 hasAuthorship W2024331999A5002495281 @default.
• W2024331999 hasAuthorship W2024331999A5028983150 @default.
• W2024331999 hasAuthorship W2024331999A5032796168 @default.
• W2024331999 hasAuthorship W2024331999A5037650113 @default.
• W2024331999 hasAuthorship W2024331999A5042365463 @default.
• W2024331999 hasAuthorship W2024331999A5057313891 @default.
• W2024331999 hasAuthorship W2024331999A5072689710 @default.
• W2024331999 hasConcept C112705442 @default.
• W2024331999 hasConcept C126322002 @default.
• W2024331999 hasConcept C134018914 @default.
• W2024331999 hasConcept C185592680 @default.
• W2024331999 hasConcept C201399114 @default.
• W2024331999 hasConcept C2777056448 @default.
• W2024331999 hasConcept C2777391703 @default.
• W2024331999 hasConcept C2779306644 @default.
• W2024331999 hasConcept C55493867 @default.
• W2024331999 hasConcept C555293320 @default.
• W2024331999 hasConcept C71924100 @default.
• W2024331999 hasConcept C98274493 @default.
• W2024331999 hasConceptScore W2024331999C112705442 @default.
• W2024331999 hasConceptScore W2024331999C126322002 @default.
• W2024331999 hasConceptScore W2024331999C134018914 @default.
• W2024331999 hasConceptScore W2024331999C185592680 @default.
• W2024331999 hasConceptScore W2024331999C201399114 @default.
• W2024331999 hasConceptScore W2024331999C2777056448 @default.
• W2024331999 hasConceptScore W2024331999C2777391703 @default.
• W2024331999 hasConceptScore W2024331999C2779306644 @default.
• W2024331999 hasConceptScore W2024331999C55493867 @default.
• W2024331999 hasConceptScore W2024331999C555293320 @default.
• W2024331999 hasConceptScore W2024331999C71924100 @default.
• W2024331999 hasConceptScore W2024331999C98274493 @default.
• W2024331999 hasIssue "3" @default.
• W2024331999 hasLocation W20243319991 @default.
• W2024331999 hasLocation W20243319992 @default.
• W2024331999 hasOpenAccess W2024331999 @default.
• W2024331999 hasPrimaryLocation W20243319991 @default.
• W2024331999 hasRelatedWork W138803513 @default.
• W2024331999 hasRelatedWork W1979252938 @default.

• next