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- W2024333404 abstract "All eukaryotic mRNA species show a characteristic individual translational efficiency under conditions of restricted polypeptide chain initiation caused by an increase in the osmolarity of the growth medium. In vaccinia virus infected L cells or HeLa cells virus mRNAs can be grouped into classes on the basis of their relative labelling under standard and hypertonic conditions. Under the latter conditions, most of the early mRNAs possess very high translational efficiencies, most of the intermediate mRNAs show an intermediate efficiency and the most prominent late mRNAs show a translational efficiency which is lower than that of other virus mRNAs but still higher than the average cellular mRNA. Late in the infection cycle virus mRNAs with a relative low translational efficiency are preferentially translated under standard growth conditions whereas early virus mRNAs which are still present and which show a higher translational resistance to hypertonic conditions are not translated. These results indicate a unique translational control operating late in the growth cycle of vaccinia virus." @default.
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- W2024333404 date "1976-08-01" @default.
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- W2024333404 title "On the Regulation of Protein Synthesis in Vaccinia Virus Infected Cells" @default.
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- W2024333404 doi "https://doi.org/10.1099/0022-1317-32-2-261" @default.
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