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• W2024333604 abstract "Abstract The effect of a carcinogen, 20-methylcholanthrene, on the quantitative utilisation of amino acids by organ cultures of the mouse prostate gland was measured by means of ion-exchange chromatography. The glands utilised leucine, isoleucine, cystine and arginine, while glutamic acid and glycine accumulated. The quantities utilised were of the same order for both treated and control cultures with the exception of arginine, which was removed more rapidly by the controls. The presence and amount of ornithine found in the medium after cultivation indicated extensive breakdown of arginine by arginase action. Measurements of arginase activity showed a striking increase in cultures grown in control medium over that of freshly isolated prostate glands. This increase also occurred when testosterone was added to the medium. Cultures grown in the presence of methylcholanthrene showed a much smaller increase in arginase activity." @default.
• W2024333604 created "2016-06-24" @default.
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• W2024333604 date "1961-08-01" @default.
• W2024333604 modified "2023-09-25" @default.
• W2024333604 title "Amino acid metabolism and arginase activity in mouse prostate glands grown in vitro with and without 20-methylcholanthrene" @default.
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• W2024333604 doi "https://doi.org/10.1016/0014-4827(61)90439-6" @default.
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