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- W2024333774 endingPage "e1004592" @default.
- W2024333774 startingPage "e1004592" @default.
- W2024333774 abstract "The genus Neisseria includes both commensal and pathogenic species which are genetically closely related. However, only meningococcus and gonococcus are important human pathogens. Very few toxins are known to be secreted by pathogenic Neisseria species. Recently, toxins secreted via type V secretion system and belonging to the widespread family of contact-dependent inhibition (CDI) toxins have been described in numerous species including meningococcus. In this study, we analyzed loci containing the maf genes in N. meningitidis and N. gonorrhoeae and proposed a novel uniform nomenclature for maf genomic islands (MGIs). We demonstrated that mafB genes encode secreted polymorphic toxins and that genes immediately downstream of mafB encode a specific immunity protein (MafI). We focused on a MafB toxin found in meningococcal strain NEM8013 and characterized its EndoU ribonuclease activity. maf genes represent 2% of the genome of pathogenic Neisseria, and are virtually absent from non-pathogenic species, thus arguing for an important biological role. Indeed, we showed that overexpression of one of the four MafB toxins of strain NEM8013 provides an advantage in competition assays, suggesting a role of maf loci in niche adaptation." @default.
- W2024333774 created "2016-06-24" @default.
- W2024333774 creator A5023873767 @default.
- W2024333774 creator A5025913172 @default.
- W2024333774 creator A5026165726 @default.
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- W2024333774 creator A5035542382 @default.
- W2024333774 creator A5043839380 @default.
- W2024333774 creator A5046570569 @default.
- W2024333774 creator A5052567877 @default.
- W2024333774 date "2015-01-08" @default.
- W2024333774 modified "2023-10-03" @default.
- W2024333774 title "A New Family of Secreted Toxins in Pathogenic Neisseria Species" @default.
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