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- W2024333976 abstract "Uncoupling proteins (UCP's) belong to the mitochondrial six-transmembrane segment carriers. Among the five known isoforms only UCP1 (thermogenin) is well characterized physiologically. In addition to shivering thermogenesis UCP1 produces heat hence aiding to maintain an optimum body temperature. The function of the other isoforms is not so well understood, since they are expressed in non-thermogenic tissues such as skeletal muscle, brain, kidney, etc. However, it is has been seen that they are over-expressed in several stress conditions, probably with the aim to reduce the production of reactive oxygen species (ROS). In plants, UCP's, are used to evaporate allelopathic compounds and pheromones through an increase in tissue temperature. In recent years several UCP's have been discovered in unicellular organisms such as Candida parapsilosis, Aspergillus fumigatus and Acanthamoeba castellanii, indicating that UCPs are distributed in all eukaryotic kingdoms. Recently we have observed an UCP-like activity in Yarrowia lipolytica's mitochondria, i.e. these mitochondria are uncoupled by fatty acids and this effect is inhibited by purine nucleotides (ATP, ADP or GDP). The same antagonist effect is observed at the level of the mitochondrial membrane potential (Δψ), that is Δψ is collapsed by fatty acids and increased by purine nucleotides. We have searched for a possible UCP's gene the genome of this yeast and have found two candidates. The first one is annotated as an oxodicarboxylate carrier and the second one as an oxaloacetate carrier. To corroborate whether one of these genes codes for a UCP, we expressed these proteins in Saccharomyces cerevisiae and sought for new UCP-like sensitivity to fatty acids and to purine nucleotides." @default.
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- W2024333976 date "2009-02-01" @default.
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- W2024333976 title "Characterization of a UCP-like Activity in Yarrowia lipolytica" @default.
- W2024333976 doi "https://doi.org/10.1016/j.bpj.2008.12.1209" @default.
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