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- W2024334274 abstract "Angiogenesis has been targeted in retinopathies, psoriasis, and a variety of cancers (colon, breast, lung, and kidney). Among these tumour types, clear cell renal cell carcinomas (RCCs) are the most vascularized tumours due to mutations of the von Hippel Lindau gene resulting in HIF-1 alpha stabilisation and overexpression of Vascular Endothelial Growth Factor (VEGF). Surgical nephrectomy remains the most efficient curative treatment for patients with noninvasive disease, while VEGF targeting has resulted in varying degrees of success for treating metastatic disease. VEGF pre-mRNA undergoes alternative splicing generating pro-angiogenic isoforms. However, the recent identification of novel splice variants of VEGF with anti-angiogenic properties has provided some insight for the lack of current treatment efficacy. Here we discuss an explanation for the relapse to anti-angiogenesis treatment as being due to either an initial or acquired resistance to the therapy. We also discuss targeting angiogenesis via SR (serine/arginine-rich) proteins implicated in VEGF splicing." @default.
- W2024334274 created "2016-06-24" @default.
- W2024334274 creator A5048478589 @default.
- W2024334274 creator A5058267199 @default.
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- W2024334274 date "2012-01-01" @default.
- W2024334274 modified "2023-10-17" @default.
- W2024334274 title "VEGF Spliced Variants: Possible Role of Anti-Angiogenesis Therapy" @default.
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- W2024334274 doi "https://doi.org/10.1155/2012/162692" @default.
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