Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024334446> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2024334446 abstract "supports the hypothesis that inhibited PARP1 is a component of the toxic DNA damage lesion. Notably, we did not isolate mutations in any genes encoding other PARP proteins, implicating PARP1 as the major mediator of this effect. Our results suggest that toxicity to normal cells in patients treated with PARP inhibitors is likely to be an on-target effect mediated via PARP1, and also identify PARP1 mutation as a possible route of resistance to PARP inhibitors in tumours. Haploid screening will be a powerful way of identifying genetic determinants of toxicity and resistance to other drugs." @default.
- W2024334446 created "2016-06-24" @default.
- W2024334446 creator A5017575332 @default.
- W2024334446 creator A5038147115 @default.
- W2024334446 creator A5048920237 @default.
- W2024334446 creator A5056547774 @default.
- W2024334446 creator A5061988702 @default.
- W2024334446 creator A5067741256 @default.
- W2024334446 creator A5074740364 @default.
- W2024334446 creator A5080204682 @default.
- W2024334446 date "2012-11-01" @default.
- W2024334446 modified "2023-09-27" @default.
- W2024334446 title "138 The MDM2 Inhibitor Nutlin-3 But Not the p53 Activator RITA Induces Loss-of-function p53 Mutations" @default.
- W2024334446 doi "https://doi.org/10.1016/s0959-8049(12)71936-6" @default.
- W2024334446 hasPublicationYear "2012" @default.
- W2024334446 type Work @default.
- W2024334446 sameAs 2024334446 @default.
- W2024334446 citedByCount "0" @default.
- W2024334446 crossrefType "journal-article" @default.
- W2024334446 hasAuthorship W2024334446A5017575332 @default.
- W2024334446 hasAuthorship W2024334446A5038147115 @default.
- W2024334446 hasAuthorship W2024334446A5048920237 @default.
- W2024334446 hasAuthorship W2024334446A5056547774 @default.
- W2024334446 hasAuthorship W2024334446A5061988702 @default.
- W2024334446 hasAuthorship W2024334446A5067741256 @default.
- W2024334446 hasAuthorship W2024334446A5074740364 @default.
- W2024334446 hasAuthorship W2024334446A5080204682 @default.
- W2024334446 hasConcept C104317684 @default.
- W2024334446 hasConcept C126322002 @default.
- W2024334446 hasConcept C143425029 @default.
- W2024334446 hasConcept C182979987 @default.
- W2024334446 hasConcept C2776192174 @default.
- W2024334446 hasConcept C2778480876 @default.
- W2024334446 hasConcept C29730261 @default.
- W2024334446 hasConcept C501734568 @default.
- W2024334446 hasConcept C502942594 @default.
- W2024334446 hasConcept C54355233 @default.
- W2024334446 hasConcept C552990157 @default.
- W2024334446 hasConcept C71924100 @default.
- W2024334446 hasConcept C82381507 @default.
- W2024334446 hasConcept C86803240 @default.
- W2024334446 hasConcept C88045685 @default.
- W2024334446 hasConceptScore W2024334446C104317684 @default.
- W2024334446 hasConceptScore W2024334446C126322002 @default.
- W2024334446 hasConceptScore W2024334446C143425029 @default.
- W2024334446 hasConceptScore W2024334446C182979987 @default.
- W2024334446 hasConceptScore W2024334446C2776192174 @default.
- W2024334446 hasConceptScore W2024334446C2778480876 @default.
- W2024334446 hasConceptScore W2024334446C29730261 @default.
- W2024334446 hasConceptScore W2024334446C501734568 @default.
- W2024334446 hasConceptScore W2024334446C502942594 @default.
- W2024334446 hasConceptScore W2024334446C54355233 @default.
- W2024334446 hasConceptScore W2024334446C552990157 @default.
- W2024334446 hasConceptScore W2024334446C71924100 @default.
- W2024334446 hasConceptScore W2024334446C82381507 @default.
- W2024334446 hasConceptScore W2024334446C86803240 @default.
- W2024334446 hasConceptScore W2024334446C88045685 @default.
- W2024334446 hasLocation W20243344461 @default.
- W2024334446 hasOpenAccess W2024334446 @default.
- W2024334446 hasPrimaryLocation W20243344461 @default.
- W2024334446 hasRelatedWork W1994288910 @default.
- W2024334446 hasRelatedWork W2000847178 @default.
- W2024334446 hasRelatedWork W2048297966 @default.
- W2024334446 hasRelatedWork W2053601921 @default.
- W2024334446 hasRelatedWork W2057882999 @default.
- W2024334446 hasRelatedWork W2083718596 @default.
- W2024334446 hasRelatedWork W2224899546 @default.
- W2024334446 hasRelatedWork W2228544728 @default.
- W2024334446 hasRelatedWork W2402334134 @default.
- W2024334446 hasRelatedWork W2536095668 @default.
- W2024334446 hasRelatedWork W2611690370 @default.
- W2024334446 hasRelatedWork W2740748274 @default.
- W2024334446 hasRelatedWork W2767273060 @default.
- W2024334446 hasRelatedWork W3003654778 @default.
- W2024334446 hasRelatedWork W3009195994 @default.
- W2024334446 hasRelatedWork W3030435769 @default.
- W2024334446 hasRelatedWork W3092193988 @default.
- W2024334446 hasRelatedWork W3109063469 @default.
- W2024334446 hasRelatedWork W3182119551 @default.
- W2024334446 hasRelatedWork W2159196431 @default.
- W2024334446 isParatext "false" @default.
- W2024334446 isRetracted "false" @default.
- W2024334446 magId "2024334446" @default.
- W2024334446 workType "article" @default.