FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024336885> ?p ?o ?g. }

• W2024336885 endingPage "2953" @default.
• W2024336885 startingPage "2946" @default.
• W2024336885 abstract "Potassium channels have been involved in epithelial tumorigenesis but the role of small-conductance Ca(2+)-activated K(+) channels is unknown. We report here that small-conductance Ca(2+)-activated K(+) channels are expressed in a highly metastasizing mammary cancer cell line, MDA-MB-435s. Patch-clamp recordings showed typical small-conductance Ca(2+)-activated K(+) channel-mediated currents sensitive to apamin, 4-aminopyridine, and tetraethylammonium. Moreover, the cells displayed a high intracellular calcium concentration, which was decreased after 24 hours of apamin treatment. By regulating membrane potential and intracellular calcium concentration, these channels were involved in MDA-MB-435s cell migration, but not in proliferation. Only SK3 protein expression was observed in these cells in contrast to SK2, which was expressed both in cancer and noncancer cell lines. Whereas small interfering RNA directed against SK3 almost totally abolished MDA-MB-435s cell migration, transient expression of SK3 increased migration of the SK3-deficient cell lines, MCF-7 and 184A1. SK3 channel was solely expressed in tumor breast biopsies and not in nontumor breast tissues. Thus, SK3 protein channel seems to be a new mediator of breast cancer cell migration and represents a potential target for a new class of anticancer agents." @default.
• W2024336885 created "2016-06-24" @default.
• W2024336885 creator A5022364654 @default.
• W2024336885 creator A5023029809 @default.
• W2024336885 creator A5033272109 @default.
• W2024336885 creator A5038788293 @default.
• W2024336885 creator A5079046089 @default.
• W2024336885 creator A5079609936 @default.
• W2024336885 creator A5090410548 @default.
• W2024336885 creator A5091747535 @default.
• W2024336885 date "2006-11-01" @default.
• W2024336885 modified "2023-10-13" @default.
• W2024336885 title "Identification of SK3 channel as a new mediator of breast cancer cell migration" @default.
• W2024336885 cites W1490915066 @default.
• W2024336885 cites W1964124586 @default.
• W2024336885 cites W1967265143 @default.
• W2024336885 cites W1968129587 @default.
• W2024336885 cites W1968135647 @default.
• W2024336885 cites W1970277917 @default.
• W2024336885 cites W1979329801 @default.
• W2024336885 cites W1979968056 @default.
• W2024336885 cites W1980345371 @default.
• W2024336885 cites W1992371433 @default.
• W2024336885 cites W1997867282 @default.
• W2024336885 cites W2022062323 @default.
• W2024336885 cites W2034245104 @default.
• W2024336885 cites W2042670053 @default.
• W2024336885 cites W2046771994 @default.
• W2024336885 cites W2049193842 @default.
• W2024336885 cites W2064821447 @default.
• W2024336885 cites W2086037471 @default.
• W2024336885 cites W2101009136 @default.
• W2024336885 cites W2109104280 @default.
• W2024336885 cites W2114443373 @default.
• W2024336885 cites W2115221887 @default.
• W2024336885 cites W2137384640 @default.
• W2024336885 cites W2140625991 @default.
• W2024336885 cites W2152226130 @default.
• W2024336885 cites W2157952220 @default.
• W2024336885 cites W2158978788 @default.
• W2024336885 cites W2181797500 @default.
• W2024336885 doi "https://doi.org/10.1158/1535-7163.mct-06-0194" @default.
• W2024336885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17121942" @default.
• W2024336885 hasPublicationYear "2006" @default.
• W2024336885 type Work @default.
• W2024336885 sameAs 2024336885 @default.
• W2024336885 citedByCount "112" @default.
• W2024336885 countsByYear W20243368852012 @default.
• W2024336885 countsByYear W20243368852013 @default.
• W2024336885 countsByYear W20243368852014 @default.
• W2024336885 countsByYear W20243368852015 @default.
• W2024336885 countsByYear W20243368852016 @default.
• W2024336885 countsByYear W20243368852017 @default.
• W2024336885 countsByYear W20243368852018 @default.
• W2024336885 countsByYear W20243368852019 @default.
• W2024336885 countsByYear W20243368852020 @default.
• W2024336885 countsByYear W20243368852021 @default.
• W2024336885 countsByYear W20243368852022 @default.
• W2024336885 countsByYear W20243368852023 @default.
• W2024336885 crossrefType "journal-article" @default.
• W2024336885 hasAuthorship W2024336885A5022364654 @default.
• W2024336885 hasAuthorship W2024336885A5023029809 @default.
• W2024336885 hasAuthorship W2024336885A5033272109 @default.
• W2024336885 hasAuthorship W2024336885A5038788293 @default.
• W2024336885 hasAuthorship W2024336885A5079046089 @default.
• W2024336885 hasAuthorship W2024336885A5079609936 @default.
• W2024336885 hasAuthorship W2024336885A5090410548 @default.
• W2024336885 hasAuthorship W2024336885A5091747535 @default.
• W2024336885 hasConcept C121608353 @default.
• W2024336885 hasConcept C126322002 @default.
• W2024336885 hasConcept C134018914 @default.
• W2024336885 hasConcept C137738243 @default.
• W2024336885 hasConcept C1491633281 @default.
• W2024336885 hasConcept C149786707 @default.
• W2024336885 hasConcept C170493617 @default.
• W2024336885 hasConcept C185592680 @default.
• W2024336885 hasConcept C2776919887 @default.
• W2024336885 hasConcept C50254741 @default.
• W2024336885 hasConcept C502942594 @default.
• W2024336885 hasConcept C55493867 @default.
• W2024336885 hasConcept C555283112 @default.
• W2024336885 hasConcept C62112901 @default.
• W2024336885 hasConcept C71924100 @default.
• W2024336885 hasConcept C79879829 @default.
• W2024336885 hasConcept C83743174 @default.
• W2024336885 hasConcept C86803240 @default.
• W2024336885 hasConcept C95444343 @default.
• W2024336885 hasConceptScore W2024336885C121608353 @default.
• W2024336885 hasConceptScore W2024336885C126322002 @default.
• W2024336885 hasConceptScore W2024336885C134018914 @default.
• W2024336885 hasConceptScore W2024336885C137738243 @default.
• W2024336885 hasConceptScore W2024336885C1491633281 @default.
• W2024336885 hasConceptScore W2024336885C149786707 @default.
• W2024336885 hasConceptScore W2024336885C170493617 @default.
• W2024336885 hasConceptScore W2024336885C185592680 @default.
• W2024336885 hasConceptScore W2024336885C2776919887 @default.
• W2024336885 hasConceptScore W2024336885C50254741 @default.
• W2024336885 hasConceptScore W2024336885C502942594 @default.

• next