Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024338419> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2024338419 endingPage "49" @default.
- W2024338419 startingPage "46" @default.
- W2024338419 abstract "Levosimendan enhances cardiac contractility by increasing myocyte sensitivity to calcium, and induces vasodilatation. Although studies have evaluated the efficacy of levosimendan in heart failure, it is not clear whether it might produce functional influence on platelet response. In this study, the effect of levosimendan on platelet aggregation was investigated. Platelet function tests were performed in 12 healthy male volunteers. Three concentrations of levosimendan solution were prepared that would result in 10, 25, and 45 ng/ml levosimendan concentrations in the blood similar to that observed after clinical therapeutic intravenous application of 0.05–0.1 μg/kg/min. Each concentration of levosimendan solution and a control diluent without levosimendan were incubated with whole blood at 37°C. After incubation for 15 min, aggregation responses were evaluated with adenosine diphosphate (ADP) (5 and 10 μM) and collagen (2 and 5 μg/ml) in platelet-rich plasma. Preincubation with all dilutions of levosimendan inhibited aggregation of platelets induced by ADP and collagen significantly. Levosimendan also inhibited significantly the secondary wave of platelet aggregation induced by ADP. The results showed that there was a relationship between levosimendan concentration and inhibition of platelet aggregation. In conclusion, this study with an in vitro model showed that levosimendan had a significant inhibitory effect on platelets in clinically relevant doses. Am. J. Hematol., 2008. © 2007 Wiley-Liss, Inc." @default.
- W2024338419 created "2016-06-24" @default.
- W2024338419 creator A5012145024 @default.
- W2024338419 creator A5042430142 @default.
- W2024338419 creator A5043775815 @default.
- W2024338419 creator A5045706755 @default.
- W2024338419 creator A5049907913 @default.
- W2024338419 creator A5049922356 @default.
- W2024338419 creator A5060747641 @default.
- W2024338419 date "2007-01-01" @default.
- W2024338419 modified "2023-10-18" @default.
- W2024338419 title "Levosimendan has an inhibitory effect on platelet function" @default.
- W2024338419 cites W1556535974 @default.
- W2024338419 cites W1804883704 @default.
- W2024338419 cites W1966922247 @default.
- W2024338419 cites W1993743949 @default.
- W2024338419 cites W2000876750 @default.
- W2024338419 cites W2017397568 @default.
- W2024338419 cites W2032520387 @default.
- W2024338419 cites W2060904229 @default.
- W2024338419 cites W2066118369 @default.
- W2024338419 cites W2080404330 @default.
- W2024338419 cites W2098740917 @default.
- W2024338419 cites W2103301522 @default.
- W2024338419 cites W2114266782 @default.
- W2024338419 cites W2117483856 @default.
- W2024338419 cites W2127139759 @default.
- W2024338419 cites W2130310240 @default.
- W2024338419 cites W2133981603 @default.
- W2024338419 cites W2157204705 @default.
- W2024338419 cites W2323986425 @default.
- W2024338419 doi "https://doi.org/10.1002/ajh.20999" @default.
- W2024338419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17654687" @default.
- W2024338419 hasPublicationYear "2007" @default.
- W2024338419 type Work @default.
- W2024338419 sameAs 2024338419 @default.
- W2024338419 citedByCount "25" @default.
- W2024338419 countsByYear W20243384192012 @default.
- W2024338419 countsByYear W20243384192014 @default.
- W2024338419 countsByYear W20243384192015 @default.
- W2024338419 countsByYear W20243384192016 @default.
- W2024338419 countsByYear W20243384192017 @default.
- W2024338419 countsByYear W20243384192019 @default.
- W2024338419 countsByYear W20243384192020 @default.
- W2024338419 countsByYear W20243384192021 @default.
- W2024338419 crossrefType "journal-article" @default.
- W2024338419 hasAuthorship W2024338419A5012145024 @default.
- W2024338419 hasAuthorship W2024338419A5042430142 @default.
- W2024338419 hasAuthorship W2024338419A5043775815 @default.
- W2024338419 hasAuthorship W2024338419A5045706755 @default.
- W2024338419 hasAuthorship W2024338419A5049907913 @default.
- W2024338419 hasAuthorship W2024338419A5049922356 @default.
- W2024338419 hasAuthorship W2024338419A5060747641 @default.
- W2024338419 hasBestOaLocation W20243384191 @default.
- W2024338419 hasConcept C126322002 @default.
- W2024338419 hasConcept C1621761 @default.
- W2024338419 hasConcept C185592680 @default.
- W2024338419 hasConcept C2777335384 @default.
- W2024338419 hasConcept C2777399203 @default.
- W2024338419 hasConcept C2778198053 @default.
- W2024338419 hasConcept C2993802102 @default.
- W2024338419 hasConcept C39133596 @default.
- W2024338419 hasConcept C71924100 @default.
- W2024338419 hasConcept C89560881 @default.
- W2024338419 hasConcept C98274493 @default.
- W2024338419 hasConceptScore W2024338419C126322002 @default.
- W2024338419 hasConceptScore W2024338419C1621761 @default.
- W2024338419 hasConceptScore W2024338419C185592680 @default.
- W2024338419 hasConceptScore W2024338419C2777335384 @default.
- W2024338419 hasConceptScore W2024338419C2777399203 @default.
- W2024338419 hasConceptScore W2024338419C2778198053 @default.
- W2024338419 hasConceptScore W2024338419C2993802102 @default.
- W2024338419 hasConceptScore W2024338419C39133596 @default.
- W2024338419 hasConceptScore W2024338419C71924100 @default.
- W2024338419 hasConceptScore W2024338419C89560881 @default.
- W2024338419 hasConceptScore W2024338419C98274493 @default.
- W2024338419 hasIssue "1" @default.
- W2024338419 hasLocation W20243384191 @default.
- W2024338419 hasLocation W20243384192 @default.
- W2024338419 hasOpenAccess W2024338419 @default.
- W2024338419 hasPrimaryLocation W20243384191 @default.
- W2024338419 hasRelatedWork W1977136153 @default.
- W2024338419 hasRelatedWork W1987505873 @default.
- W2024338419 hasRelatedWork W2007095910 @default.
- W2024338419 hasRelatedWork W2024338419 @default.
- W2024338419 hasRelatedWork W2036054103 @default.
- W2024338419 hasRelatedWork W2044492138 @default.
- W2024338419 hasRelatedWork W2056880539 @default.
- W2024338419 hasRelatedWork W2082196177 @default.
- W2024338419 hasRelatedWork W2408953331 @default.
- W2024338419 hasRelatedWork W2472963372 @default.
- W2024338419 hasVolume "83" @default.
- W2024338419 isParatext "false" @default.
- W2024338419 isRetracted "false" @default.
- W2024338419 magId "2024338419" @default.
- W2024338419 workType "article" @default.