FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024339512> ?p ?o ?g. }

• W2024339512 endingPage "258" @default.
• W2024339512 startingPage "246" @default.
• W2024339512 abstract "The objective of this investigation was to distinguish which of the catalytic features of enzyme action is principally responsible for conferring the observed insensitivity of trout brain acetylcholinesterase (AChE; EC 3.1.1.7) to in vitro inhibition by organophosphates. The experimental design consisted of comparing the kinetic constants for the hydrolysis of a series of acylthiocholine substrates as well as the inhibition constants for a homologous series of dialkyl p-nitrophenyl phosphates among AChE from rats, hens, and trout. Chicken and rat brain AChE failed to distinguish between acetyl- and propionylthiocholine as inferred from the comparable Michaelis-Menten constants (Km), whereas trout brain AChE exhibited a much higher affinity for acetylthiocholine than for either of the two larger analogs. Diethyl p-nitrophenyl phosphate was the most potent inhibitor toward chicken and rat brain AChE, whereas the IC50 for the trout enzyme increased progressively between dimethyl and di-n-propyl p-nitrophenyl phosphate. The kinetic constants revealed that a significant determinant of inhibitor potency in the chicken and rat is steric exclusion as reflected by changes in the dissociation constant (Kd) which paralleled the changes in IC50 and ki. Conversely, Kd was 120- to 1450-fold higher and did not vary significantly for trout brain AChE. Instead, the phosphorylation rate constant (kp) for trout brain AChE decreased with progressive methylene substitutions. The kinetic data suggest that trout brain AChE not only possesses less steric tolerance, but also has a weaker nucleophile at the esteratic subsite, both of which may be important factors in conferring the observed insensitivity of trout to acute organophosphate intoxication." @default.
• W2024339512 created "2016-06-24" @default.
• W2024339512 creator A5002762245 @default.
• W2024339512 creator A5035089704 @default.
• W2024339512 date "1990-06-01" @default.
• W2024339512 modified "2023-10-07" @default.
• W2024339512 title "Molecular determinants of the species-selective inhibition of brain acetylcholinesterase" @default.
• W2024339512 cites W1516387619 @default.
• W2024339512 cites W1538351630 @default.
• W2024339512 cites W1775749144 @default.
• W2024339512 cites W1970700856 @default.
• W2024339512 cites W1971048984 @default.
• W2024339512 cites W1972892080 @default.
• W2024339512 cites W1983431774 @default.
• W2024339512 cites W1986232872 @default.
• W2024339512 cites W1987377288 @default.
• W2024339512 cites W1989036449 @default.
• W2024339512 cites W1993585343 @default.
• W2024339512 cites W1995593375 @default.
• W2024339512 cites W1998194919 @default.
• W2024339512 cites W2000967048 @default.
• W2024339512 cites W2001877444 @default.
• W2024339512 cites W2003355337 @default.
• W2024339512 cites W2013644867 @default.
• W2024339512 cites W2015778051 @default.
• W2024339512 cites W2020468101 @default.
• W2024339512 cites W2021496995 @default.
• W2024339512 cites W2028963815 @default.
• W2024339512 cites W2031110696 @default.
• W2024339512 cites W2032035877 @default.
• W2024339512 cites W2032177550 @default.
• W2024339512 cites W2051883830 @default.
• W2024339512 cites W2054726355 @default.
• W2024339512 cites W2054979333 @default.
• W2024339512 cites W2061506011 @default.
• W2024339512 cites W2070351205 @default.
• W2024339512 cites W2070856763 @default.
• W2024339512 cites W2076915778 @default.
• W2024339512 cites W2080798693 @default.
• W2024339512 cites W2089753046 @default.
• W2024339512 cites W2095037836 @default.
• W2024339512 cites W2153843283 @default.
• W2024339512 cites W2317053404 @default.
• W2024339512 cites W2326367868 @default.
• W2024339512 cites W2436781212 @default.
• W2024339512 doi "https://doi.org/10.1016/0041-008x(90)90299-a" @default.
• W2024339512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2363176" @default.
• W2024339512 hasPublicationYear "1990" @default.
• W2024339512 type Work @default.
• W2024339512 sameAs 2024339512 @default.
• W2024339512 citedByCount "44" @default.
• W2024339512 countsByYear W20243395122012 @default.
• W2024339512 countsByYear W20243395122013 @default.
• W2024339512 countsByYear W20243395122014 @default.
• W2024339512 countsByYear W20243395122015 @default.
• W2024339512 countsByYear W20243395122016 @default.
• W2024339512 countsByYear W20243395122017 @default.
• W2024339512 countsByYear W20243395122020 @default.
• W2024339512 crossrefType "journal-article" @default.
• W2024339512 hasAuthorship W2024339512A5002762245 @default.
• W2024339512 hasAuthorship W2024339512A5035089704 @default.
• W2024339512 hasConcept C170493617 @default.
• W2024339512 hasConcept C181199279 @default.
• W2024339512 hasConcept C185592680 @default.
• W2024339512 hasConcept C201194858 @default.
• W2024339512 hasConcept C202751555 @default.
• W2024339512 hasConcept C2778816929 @default.
• W2024339512 hasConcept C2779059548 @default.
• W2024339512 hasConcept C2779363728 @default.
• W2024339512 hasConcept C2909208804 @default.
• W2024339512 hasConcept C2909509320 @default.
• W2024339512 hasConcept C505870484 @default.
• W2024339512 hasConcept C55493867 @default.
• W2024339512 hasConcept C57992300 @default.
• W2024339512 hasConcept C71240020 @default.
• W2024339512 hasConcept C74998103 @default.
• W2024339512 hasConcept C86803240 @default.
• W2024339512 hasConceptScore W2024339512C170493617 @default.
• W2024339512 hasConceptScore W2024339512C181199279 @default.
• W2024339512 hasConceptScore W2024339512C185592680 @default.
• W2024339512 hasConceptScore W2024339512C201194858 @default.
• W2024339512 hasConceptScore W2024339512C202751555 @default.
• W2024339512 hasConceptScore W2024339512C2778816929 @default.
• W2024339512 hasConceptScore W2024339512C2779059548 @default.
• W2024339512 hasConceptScore W2024339512C2779363728 @default.
• W2024339512 hasConceptScore W2024339512C2909208804 @default.
• W2024339512 hasConceptScore W2024339512C2909509320 @default.
• W2024339512 hasConceptScore W2024339512C505870484 @default.
• W2024339512 hasConceptScore W2024339512C55493867 @default.
• W2024339512 hasConceptScore W2024339512C57992300 @default.
• W2024339512 hasConceptScore W2024339512C71240020 @default.
• W2024339512 hasConceptScore W2024339512C74998103 @default.
• W2024339512 hasConceptScore W2024339512C86803240 @default.
• W2024339512 hasIssue "2" @default.
• W2024339512 hasLocation W20243395121 @default.
• W2024339512 hasLocation W20243395122 @default.
• W2024339512 hasOpenAccess W2024339512 @default.
• W2024339512 hasPrimaryLocation W20243395121 @default.

• next