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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024341713> ?p ?o ?g. }

• W2024341713 endingPage "749" @default.
• W2024341713 startingPage "743" @default.
• W2024341713 abstract "The goal of this study was to investigate the cellular localization and the interaction between caveolin-1 and ABCA1 in cholesterol-loaded aortic endothelial cells after HDL incubation. Immunofluorescence confocal microscopy showed that ABCA1 was found primarily on the cell surface, whereas caveolin-1 was revealed on the cell surface and in the cytoplasm. The HDL appeared to colocalize with ABCA1 and caveolin-1 on the cell surface. No free HDL was revealed in the cytoplasm. The HDL was colocalized neither with early endosome marker (CD71) nor with late endosome marker (LAMP2). The chemical cross-linking and immunoprecipitation analysis revealed that ABCA1 binds directly to both HDL and caveolin-1, whereas HDL does not bind directly to caveolin-1. The studies provide evidence for a direct interaction between ABCA1 and HDL, ABCA1 and caveolin-1, but not HDL and caveolin-1, indicating that ABCA1 may act as a structural platform between HDL and caveolin-1 on the cell surface during cellular cholesterol efflux." @default.
• W2024341713 created "2016-06-24" @default.
• W2024341713 creator A5018891714 @default.
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• W2024341713 date "2005-07-01" @default.
• W2024341713 modified "2023-09-26" @default.
• W2024341713 title "Cellular localization and interaction of ABCA1 and caveolin-1 in aortic endothelial cells after HDL incubation" @default.
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• W2024341713 doi "https://doi.org/10.1016/j.bbrc.2005.05.019" @default.
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