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- W2024342657 abstract "Further studies on a hamster lung fibroblast mutant with a marked defect in the enzyme glucose-6-phosphate isomerase revealed the following differences in its transport regulatory patterns as compared with its parental PGI+ strain. If both strains were maintained over 24 hours in media deprived of L-glutamine, the PGI+ strain was still able to develop the glucose-mediated down-regulation of hexose transport (transport ‘curb’). In contrast the PGI− mutant was unable to develop a transport curb with any of the aldohexoses, including glucose. However, glucose complemented either with L-glutamine, L-glutamate, or pyruvate or with D-mannose, restored the ability of the mutant to regulate its hexose transport system. From these studies, it seems that two oxidative pathways are indeed needed to operate in order to preserve the so-called glucose-mediated hexose transport curb." @default.
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- W2024342657 date "1963-06-01" @default.
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- W2024342657 title "Metabolism and cell wall structure of a mutant of salmonella typhimurium deficient in phosphoglucose isomerase" @default.
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- W2024342657 doi "https://doi.org/10.1016/0006-291x(63)90086-x" @default.
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