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- W2024342877 abstract "The effects of captopril (SQ 14.225), an orally active inhibitor of angiotensin converting enzyme, were investigated in a dose titration study of primary hypertension. In 32 patients 4 weeks titration with captopril gave a mean blood pressure (BP) reduction of 26/16 mmHg supine and 30/16 mmHg standing. No serious side effects were observed. The BP lowering effect was related to pre-treatment plasma renin activity and was less in low renin hypertension (p < 0.05). Captopril reduced angiotensin II (p < 0.05), plasma (p < 0.005) and urinary aldosterone (p < 0.001) as well as urinary kallikrein excretion (p < 0.005). Captopril (SQ 14.225) is a competitive inhibitor of peptidyl dipeptide hydrolase, also known as angiotensin converting enzyme (ACE) or kininase II, which converts angiotensin I (A I) into angiotensin II (A II), hydrolyzes des-Asp-angiotensin I to angiotensin III (A III) and inactivates bradykinin (BK) (19). Captopril has potent antihypertensive effects when used in human hypertension (review, 3) especially when the renin-angiotensin-aldosterone system (RAAS) is activated. To further investigate the mode of action and the hypotensive effect of captopril, we measured plasma renin activity (PRA), A II, plasma (PA) and urinary aldosterone excretion (UA) and urinary kallikrein excretion (UK) in 32 patients with established primary (essential) hypertension." @default.
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- W2024342877 date "2009-04-24" @default.
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- W2024342877 title "CAPTOPRIL IN PRIMARY HYPERTENSION" @default.
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- W2024342877 doi "https://doi.org/10.1111/j.0954-6820.1981.tb02628.x" @default.
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