FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024342938> ?p ?o ?g. }

• W2024342938 abstract "The existence of negative correlations between degrees of interacting proteins is being discussed since such negative degree correlations were found for the large-scale yeast protein-protein interaction (PPI) network of Ito et al. More recent studies observed no such negative correlations for high-confidence interaction sets. In this article, we analyzed a range of experimentally derived interaction networks to understand the role and prevalence of degree correlations in PPI networks. We investigated how degree correlations influence the structure of networks and their tolerance against perturbations such as the targeted deletion of hubs. For each PPI network, we simulated uncorrelated, positively and negatively correlated reference networks. Here, a simple model was developed which can create different types of degree correlations in a network without changing the degree distribution. Differences in static properties associated with degree correlations were compared by analyzing the network characteristics of the original PPI and reference networks. Dynamics were compared by simulating the effect of a selective deletion of hubs in all networks. Considerable differences between the network types were found for the number of components in the original networks. Negatively correlated networks are fragmented into significantly less components than observed for positively correlated networks. On the other hand, the selective deletion of hubs showed an increased structural tolerance to these deletions for the positively correlated networks. This results in a lower rate of interaction loss in these networks compared to the negatively correlated networks and a decreased disintegration rate. Interestingly, real PPI networks are most similar to the randomly correlated references with respect to all properties analyzed. Thus, although structural properties of networks can be modified considerably by degree correlations, biological PPI networks do not actually seem to make use of this possibility." @default.
• W2024342938 created "2016-06-24" @default.
• W2024342938 creator A5010083961 @default.
• W2024342938 creator A5068859428 @default.
• W2024342938 date "2007-08-09" @default.
• W2024342938 modified "2023-10-10" @default.
• W2024342938 title "Influence of degree correlations on network structure and stability in protein-protein interaction networks" @default.
• W2024342938 cites W1983202741 @default.
• W2024342938 cites W1988757233 @default.
• W2024342938 cites W1994803330 @default.
• W2024342938 cites W2001054969 @default.
• W2024342938 cites W2022245605 @default.
• W2024342938 cites W2024839376 @default.
• W2024342938 cites W2034509354 @default.
• W2024342938 cites W2037433020 @default.
• W2024342938 cites W2047693963 @default.
• W2024342938 cites W2060464767 @default.
• W2024342938 cites W2065304353 @default.
• W2024342938 cites W2101181377 @default.
• W2024342938 cites W2102155970 @default.
• W2024342938 cites W2104315543 @default.
• W2024342938 cites W2112090702 @default.
• W2024342938 cites W2113019448 @default.
• W2024342938 cites W2130790725 @default.
• W2024342938 cites W2132582966 @default.
• W2024342938 cites W2143537765 @default.
• W2024342938 cites W2156737316 @default.
• W2024342938 cites W2158597576 @default.
• W2024342938 cites W2163630575 @default.
• W2024342938 cites W2167869241 @default.
• W2024342938 cites W3103071483 @default.
• W2024342938 doi "https://doi.org/10.1186/1471-2105-8-297" @default.
• W2024342938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1995226" @default.
• W2024342938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17688687" @default.
• W2024342938 hasPublicationYear "2007" @default.
• W2024342938 type Work @default.
• W2024342938 sameAs 2024342938 @default.
• W2024342938 citedByCount "35" @default.
• W2024342938 countsByYear W20243429382012 @default.
• W2024342938 countsByYear W20243429382013 @default.
• W2024342938 countsByYear W20243429382014 @default.
• W2024342938 countsByYear W20243429382015 @default.
• W2024342938 countsByYear W20243429382016 @default.
• W2024342938 countsByYear W20243429382017 @default.
• W2024342938 countsByYear W20243429382019 @default.
• W2024342938 countsByYear W20243429382020 @default.
• W2024342938 countsByYear W20243429382021 @default.
• W2024342938 countsByYear W20243429382022 @default.
• W2024342938 countsByYear W20243429382023 @default.
• W2024342938 crossrefType "journal-article" @default.
• W2024342938 hasAuthorship W2024342938A5010083961 @default.
• W2024342938 hasAuthorship W2024342938A5068859428 @default.
• W2024342938 hasBestOaLocation W20243429381 @default.
• W2024342938 hasConcept C105795698 @default.
• W2024342938 hasConcept C112972136 @default.
• W2024342938 hasConcept C114614502 @default.
• W2024342938 hasConcept C117220453 @default.
• W2024342938 hasConcept C11804247 @default.
• W2024342938 hasConcept C119857082 @default.
• W2024342938 hasConcept C121332964 @default.
• W2024342938 hasConcept C169345407 @default.
• W2024342938 hasConcept C186060115 @default.
• W2024342938 hasConcept C24890656 @default.
• W2024342938 hasConcept C2524010 @default.
• W2024342938 hasConcept C25580894 @default.
• W2024342938 hasConcept C2775997480 @default.
• W2024342938 hasConcept C2909613950 @default.
• W2024342938 hasConcept C2988224531 @default.
• W2024342938 hasConcept C33923547 @default.
• W2024342938 hasConcept C34947359 @default.
• W2024342938 hasConcept C41008148 @default.
• W2024342938 hasConcept C54355233 @default.
• W2024342938 hasConcept C80444323 @default.
• W2024342938 hasConcept C86803240 @default.
• W2024342938 hasConcept C87414783 @default.
• W2024342938 hasConceptScore W2024342938C105795698 @default.
• W2024342938 hasConceptScore W2024342938C112972136 @default.
• W2024342938 hasConceptScore W2024342938C114614502 @default.
• W2024342938 hasConceptScore W2024342938C117220453 @default.
• W2024342938 hasConceptScore W2024342938C11804247 @default.
• W2024342938 hasConceptScore W2024342938C119857082 @default.
• W2024342938 hasConceptScore W2024342938C121332964 @default.
• W2024342938 hasConceptScore W2024342938C169345407 @default.
• W2024342938 hasConceptScore W2024342938C186060115 @default.
• W2024342938 hasConceptScore W2024342938C24890656 @default.
• W2024342938 hasConceptScore W2024342938C2524010 @default.
• W2024342938 hasConceptScore W2024342938C25580894 @default.
• W2024342938 hasConceptScore W2024342938C2775997480 @default.
• W2024342938 hasConceptScore W2024342938C2909613950 @default.
• W2024342938 hasConceptScore W2024342938C2988224531 @default.
• W2024342938 hasConceptScore W2024342938C33923547 @default.
• W2024342938 hasConceptScore W2024342938C34947359 @default.
• W2024342938 hasConceptScore W2024342938C41008148 @default.
• W2024342938 hasConceptScore W2024342938C54355233 @default.
• W2024342938 hasConceptScore W2024342938C80444323 @default.
• W2024342938 hasConceptScore W2024342938C86803240 @default.
• W2024342938 hasConceptScore W2024342938C87414783 @default.
• W2024342938 hasIssue "1" @default.
• W2024342938 hasLocation W20243429381 @default.
• W2024342938 hasLocation W20243429382 @default.

• next