Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024346970> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2024346970 endingPage "269" @default.
- W2024346970 startingPage "263" @default.
- W2024346970 abstract "Paracetamol is the most commonly administered medicine to children. A recent study highlighted the risk of overdose of paracetamol using British National Formulary for Children (BNFC) age-based dosing guidelines. This current study assesses the safety of changes to the UK paracetamol product dosing system proposed by the Medicines and Healthcare products Regulatory Authority (MHRA) which include a larger number of narrower age bands and a single dose per age band.Theoretical comparison of the proposed MHRA dosing system with the product dosing instructions of a commonly prescribed form of paracetamol in the UK.United Kingdom Participants Proposed MHRA dosing recommendations and current product dosing instructions were compared using a previously validated model.For both dosing recommendations, single and cumulative daily doses of paracetamol for boys and girls at the 9th, 50th and 91st centiles for weight were calculated for 3 month, 1 year, 6 year and 12 year age groups.With the current product dosing instructions, underweight children are at risk of receiving approximately two times the recommended single and cumulative daily dose of paracetamol, particularly at age 1 year and 6 years. This risk is negligible when the same model is applied to the proposed MHRA dosing system, whereby underweight, average weight and overweight children at all ages receive doses marginally above or within the recommended dose range or limit.The proposed MHRA dosing recommendations for paracetamol use in children are effective at reducing the risk of paracetamol overdose in children of all ages, when compared with current product dosing instructions." @default.
- W2024346970 created "2016-06-24" @default.
- W2024346970 creator A5008023420 @default.
- W2024346970 creator A5010020824 @default.
- W2024346970 creator A5022070375 @default.
- W2024346970 creator A5059164140 @default.
- W2024346970 date "2012-05-22" @default.
- W2024346970 modified "2023-10-14" @default.
- W2024346970 title "Proposed MHRA changes to UK children's paracetamol dosing recommendations: modelling study" @default.
- W2024346970 cites W2023607148 @default.
- W2024346970 cites W2082849382 @default.
- W2024346970 doi "https://doi.org/10.1258/jrsm.2012.110330" @default.
- W2024346970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3380232" @default.
- W2024346970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22617049" @default.
- W2024346970 hasPublicationYear "2012" @default.
- W2024346970 type Work @default.
- W2024346970 sameAs 2024346970 @default.
- W2024346970 citedByCount "6" @default.
- W2024346970 countsByYear W20243469702014 @default.
- W2024346970 countsByYear W20243469702017 @default.
- W2024346970 countsByYear W20243469702020 @default.
- W2024346970 countsByYear W20243469702022 @default.
- W2024346970 countsByYear W20243469702023 @default.
- W2024346970 crossrefType "journal-article" @default.
- W2024346970 hasAuthorship W2024346970A5008023420 @default.
- W2024346970 hasAuthorship W2024346970A5010020824 @default.
- W2024346970 hasAuthorship W2024346970A5022070375 @default.
- W2024346970 hasAuthorship W2024346970A5059164140 @default.
- W2024346970 hasBestOaLocation W20243469701 @default.
- W2024346970 hasConcept C100406419 @default.
- W2024346970 hasConcept C126322002 @default.
- W2024346970 hasConcept C187212893 @default.
- W2024346970 hasConcept C2777288759 @default.
- W2024346970 hasConcept C2780586474 @default.
- W2024346970 hasConcept C2781121325 @default.
- W2024346970 hasConcept C511355011 @default.
- W2024346970 hasConcept C71924100 @default.
- W2024346970 hasConcept C98274493 @default.
- W2024346970 hasConceptScore W2024346970C100406419 @default.
- W2024346970 hasConceptScore W2024346970C126322002 @default.
- W2024346970 hasConceptScore W2024346970C187212893 @default.
- W2024346970 hasConceptScore W2024346970C2777288759 @default.
- W2024346970 hasConceptScore W2024346970C2780586474 @default.
- W2024346970 hasConceptScore W2024346970C2781121325 @default.
- W2024346970 hasConceptScore W2024346970C511355011 @default.
- W2024346970 hasConceptScore W2024346970C71924100 @default.
- W2024346970 hasConceptScore W2024346970C98274493 @default.
- W2024346970 hasIssue "6" @default.
- W2024346970 hasLocation W20243469701 @default.
- W2024346970 hasLocation W20243469702 @default.
- W2024346970 hasLocation W20243469703 @default.
- W2024346970 hasLocation W20243469704 @default.
- W2024346970 hasOpenAccess W2024346970 @default.
- W2024346970 hasPrimaryLocation W20243469701 @default.
- W2024346970 hasRelatedWork W130814904 @default.
- W2024346970 hasRelatedWork W1960749805 @default.
- W2024346970 hasRelatedWork W2065963645 @default.
- W2024346970 hasRelatedWork W2103497017 @default.
- W2024346970 hasRelatedWork W2358134443 @default.
- W2024346970 hasRelatedWork W2520113602 @default.
- W2024346970 hasRelatedWork W2783317547 @default.
- W2024346970 hasRelatedWork W4242945315 @default.
- W2024346970 hasRelatedWork W1897789714 @default.
- W2024346970 hasRelatedWork W2140299639 @default.
- W2024346970 hasVolume "105" @default.
- W2024346970 isParatext "false" @default.
- W2024346970 isRetracted "false" @default.
- W2024346970 magId "2024346970" @default.
- W2024346970 workType "article" @default.