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• W2024347761 abstract "This study was designed to assess resting energy expenditure (REE) and nutritional status in children with hepatic and prehepatic portal hypertension in comparison with healthy controls. Twenty-five patients with portal hypertension (PHT) and a history of variceal bleeding were compared with 14 healthy volunteers selected after matching for age and sex. PHT patients were allocated to one of two groups: 11 children with liver cirrhosis and/or chronic hepatitis, aged 14.0 ± 3.3 y (means ± SD) or 14 children with extrahepatic portal vein obstruction, aged 12.3 ± 2.8 y. The control group consisted of 14 healthy children, aged 14.0 ± 1.8 y. REE (indirect calorimetry) assessed after an overnight fast was significantly higher in PHT patients than in controls when related to body mass (143.7 ± 29.5 and 116.1 ± 5.9 kJ/kg, respectively; p < 0.004), lean body mass (168.0 ± 28.9 and 146.4 ± 14.1 kJ/kg, respectively; p < 0.02), and body surface area (7480 ± 736 and 6590 ± 567 kJ/1.73 m2, respectively; p < 0.001). The ratios of measured REE to basal energy expenditure calculated from standard equations (Schofield equations) indicated higher REE in PHT patients (102.24 ± 6.90% and 93.54 ± 4.47%, respectively; p < 0.001). Fat was the predominant source of energy in both PHT patients and controls; the percentage of nonprotein energy derived from carbohydrate oxidation was equaled: 36.04 ± 18.84% and 37.15 ± 15.71%, respectively. Analysis of percentage of undernutrition in PHT patients and controls revealed significant differences (44% and 21%, respectively; p < 0.001). Children with PHT are susceptible to malnutrition and have elevated REE compared with healthy controls. Fat is the principal basal state oxidative substrate for patients with PHT and healthy children." @default.
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• W2024347761 date "1996-07-01" @default.
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• W2024347761 title "Energy metabolism in portal hypertension in children" @default.
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• W2024347761 doi "https://doi.org/10.1016/s0899-9007(96)91719-0" @default.
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