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- W2024348563 abstract "Penclomedine (NSC-338720) is a low melting point, poorly water-soluble cytotoxic agent with good solubility in triglycerides and a high octanol/water partition coefficient. Its pharmacokinetics in anesthetized rats was studied after i.v. bolus injection of a soybean oil emulsion. Penclomedine displayed biexponential behavior with an apparent t12 (± SE) of 1.9 ± 0.3 h and a clearance of 3.3 ± 0.1 ml/min per kg. After intraduodenal administration to anesthetized rats as either a 10% o/w emulsion of tributyrin, trioctanoin, triolein, soybean oil or mineral oil, or as a suspension, the rank order of absolute bioavailability was trioctanoin > soybean oil ≈ triolein > mineral oil > tributyrin > suspension. The results were rationalized by assuming that drug release from the emulsions was by a combination of vehicle metabolism and diffusional drug release. The poor bioavailability from tributyrin was rationalized by the rapid release of penclomedine resulting in its possible precipitation and subsequent need to redissolve." @default.
- W2024348563 created "2016-06-24" @default.
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- W2024348563 date "1992-01-01" @default.
- W2024348563 modified "2023-10-16" @default.
- W2024348563 title "Systemic bioavailability of penclomedine (NSC-338720) from oil-in-water emulsions administered intraduodenally to rats" @default.
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- W2024348563 doi "https://doi.org/10.1016/0378-5173(92)90374-b" @default.
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