FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024349135> ?p ?o ?g. }

• W2024349135 endingPage "25" @default.
• W2024349135 startingPage "18" @default.
• W2024349135 abstract "1.|The saturation function of NADP+ for glucose-6-phosphate dehydrogenase (d-glucose 6-phosphate: NADP oxidoreductase, EC 1.1.1.49) from human erythrocytes (electrophoretic type A) is sigmoid-shaped under certain experimental conditions. If the data are plotted in terms of Hill's equation (J. Monod, J.-P. Changeux and F. Jacob, J. Mol. Biol., 6 (1963) 306), the value of the interaction coefficient is n = 1.69 at 27° and pH 8.0. 2.|These kinetic data can be interpreted as indicative of the existence of at least two NADP+-binding sites on the enzyme, with a transition from low to high affinity for NADP+ when the concentration of NADP+ is increased. A simple method for calculating the two corresponding dissociation constants is presented, and the approximate values obtained are Ks1 = 45 μM, Ks2 = 13 μM rrespectively. 3.|NADPH inhibits erythrocyte glucose-6-phosphate dehydrogenase (Ki = 16 μM). The kinetics of inhibition can be interpreted in terms of the superimposition of two effects of NADPH: (a) competition with NADP+ for (possibly identical) binding site(s), and (b) enhancement of the affinity for NADP+ of the remaining binding site(s). As a result, the cooperativity of NADP+ molecules is decreased in the presence of NADPH, and NADPH has a paradoxical activating effect when the concentration of NADP+ is very low. 4.|Since the concentrations of NADP+ and NADPH, in erythrocytes, are of the same order of magnitude, as the dissociation constants derived here, it appears that the changes in affinity induced by NADP+ and the product inhibition by NADPH may represent a physiological mechanism for the regulation of glucose-6-phosphate dehydrogenase activity in the red cell." @default.
• W2024349135 created "2016-06-24" @default.
• W2024349135 creator A5035828284 @default.
• W2024349135 date "1967-09-01" @default.
• W2024349135 modified "2023-10-15" @default.
• W2024349135 title "Regulation of the activity of glucose-6-phosphate dehydrogenase by NADP+ and NADPH" @default.
• W2024349135 cites W1580061396 @default.
• W2024349135 cites W1592277260 @default.
• W2024349135 cites W175509376 @default.
• W2024349135 cites W1885778179 @default.
• W2024349135 cites W196901475 @default.
• W2024349135 cites W1982614633 @default.
• W2024349135 cites W1995754154 @default.
• W2024349135 cites W1998093640 @default.
• W2024349135 cites W200857827 @default.
• W2024349135 cites W2010612544 @default.
• W2024349135 cites W2020572214 @default.
• W2024349135 cites W204901863 @default.
• W2024349135 cites W2050643839 @default.
• W2024349135 cites W2169817681 @default.
• W2024349135 doi "https://doi.org/10.1016/0005-2744(67)90069-1" @default.
• W2024349135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4383500" @default.
• W2024349135 hasPublicationYear "1967" @default.
• W2024349135 type Work @default.
• W2024349135 sameAs 2024349135 @default.
• W2024349135 citedByCount "77" @default.
• W2024349135 countsByYear W20243491352012 @default.
• W2024349135 countsByYear W20243491352013 @default.
• W2024349135 countsByYear W20243491352014 @default.
• W2024349135 countsByYear W20243491352015 @default.
• W2024349135 countsByYear W20243491352017 @default.
• W2024349135 countsByYear W20243491352018 @default.
• W2024349135 countsByYear W20243491352019 @default.
• W2024349135 countsByYear W20243491352021 @default.
• W2024349135 countsByYear W20243491352023 @default.
• W2024349135 crossrefType "journal-article" @default.
• W2024349135 hasAuthorship W2024349135A5035828284 @default.
• W2024349135 hasConcept C102931765 @default.
• W2024349135 hasConcept C147789679 @default.
• W2024349135 hasConcept C166014724 @default.
• W2024349135 hasConcept C170493617 @default.
• W2024349135 hasConcept C181199279 @default.
• W2024349135 hasConcept C185592680 @default.
• W2024349135 hasConcept C187250156 @default.
• W2024349135 hasConcept C2776317432 @default.
• W2024349135 hasConcept C2779268744 @default.
• W2024349135 hasConcept C2780196906 @default.
• W2024349135 hasConcept C55493867 @default.
• W2024349135 hasConcept C71240020 @default.
• W2024349135 hasConcept C74998103 @default.
• W2024349135 hasConcept C75520062 @default.
• W2024349135 hasConceptScore W2024349135C102931765 @default.
• W2024349135 hasConceptScore W2024349135C147789679 @default.
• W2024349135 hasConceptScore W2024349135C166014724 @default.
• W2024349135 hasConceptScore W2024349135C170493617 @default.
• W2024349135 hasConceptScore W2024349135C181199279 @default.
• W2024349135 hasConceptScore W2024349135C185592680 @default.
• W2024349135 hasConceptScore W2024349135C187250156 @default.
• W2024349135 hasConceptScore W2024349135C2776317432 @default.
• W2024349135 hasConceptScore W2024349135C2779268744 @default.
• W2024349135 hasConceptScore W2024349135C2780196906 @default.
• W2024349135 hasConceptScore W2024349135C55493867 @default.
• W2024349135 hasConceptScore W2024349135C71240020 @default.
• W2024349135 hasConceptScore W2024349135C74998103 @default.
• W2024349135 hasConceptScore W2024349135C75520062 @default.
• W2024349135 hasIssue "1" @default.
• W2024349135 hasLocation W20243491351 @default.
• W2024349135 hasLocation W20243491352 @default.
• W2024349135 hasOpenAccess W2024349135 @default.
• W2024349135 hasPrimaryLocation W20243491351 @default.
• W2024349135 hasRelatedWork W1004292963 @default.
• W2024349135 hasRelatedWork W1965064962 @default.
• W2024349135 hasRelatedWork W1986169335 @default.
• W2024349135 hasRelatedWork W1997135566 @default.
• W2024349135 hasRelatedWork W2022546465 @default.
• W2024349135 hasRelatedWork W2067253151 @default.
• W2024349135 hasRelatedWork W2075856071 @default.
• W2024349135 hasRelatedWork W2078068721 @default.
• W2024349135 hasRelatedWork W4205106225 @default.
• W2024349135 hasRelatedWork W2092615839 @default.
• W2024349135 hasVolume "146" @default.
• W2024349135 isParatext "false" @default.
• W2024349135 isRetracted "false" @default.
• W2024349135 magId "2024349135" @default.
• W2024349135 workType "article" @default.