Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024349152> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2024349152 endingPage "173" @default.
- W2024349152 startingPage "166" @default.
- W2024349152 abstract "The ability of the plant flavonol quercetin and its conjugated form quercetin-3-glucoside, compared to that of the anthocyanin cyanidin-3-glucoside, to interfere with 3′,5′-cyclic adenosine monophosphate (cAMP) efflux was investigated in cultured human retinal pigment epithelial (HRPE) cells. HRPE cells were stimulated for a time course with 1 μM adrenaline, in the presence and absence of increasing concentrations of anthocyanins or flavonols, then intracellular and extracellular cAMP levels obtained from whole cells and cAMP synthetized by the activity of adenylate cyclase in cell membrane fractions were determined by radiochemical assay. The treatment with either compound caused a significant lowering in extracellular cAMP concentrations deriving from a time course cell stimulation with 1 μM epinephrine. As to quercetin, the effect was shown to rely on the inhibition of cAMP efflux transporters. In the case of the glycoside, it was found to depend on the contrary on a reduction in the extent of epinephrine stimulation. Consistently, quercetin-3-glucoside inhibited the epinephrine-stimulated activity of adenylyl cyclase in membrane preparations, while quercetin was ineffective. The anthocyanin cyanidin-3-glucoside exerted similar effects as quercetin-3-glucoside. Results strengthen the diverse effect of the glucosides versus the corresponding aglycones. Since differently from flavonols, anthocyanins are present in human plasma in their glycosylated form, the aglycone or glycoside forms of these plant secondary metabolites might therefore be utilized as synergistic regulators of cAMP homeostasis for therapeutical purposes." @default.
- W2024349152 created "2016-06-24" @default.
- W2024349152 creator A5026683831 @default.
- W2024349152 creator A5040590261 @default.
- W2024349152 creator A5066998394 @default.
- W2024349152 date "2015-01-01" @default.
- W2024349152 modified "2023-09-27" @default.
- W2024349152 title "Quercetin and quercetin-3-O-glucoside interact with different components of the cAMP signaling cascade in human retinal pigment epithelial cells" @default.
- W2024349152 cites W1503291682 @default.
- W2024349152 cites W1517339234 @default.
- W2024349152 cites W1970924452 @default.
- W2024349152 cites W1974298795 @default.
- W2024349152 cites W1974781285 @default.
- W2024349152 cites W1987397258 @default.
- W2024349152 cites W1990164787 @default.
- W2024349152 cites W1992862012 @default.
- W2024349152 cites W1997074281 @default.
- W2024349152 cites W2000173623 @default.
- W2024349152 cites W2013654757 @default.
- W2024349152 cites W2016676148 @default.
- W2024349152 cites W2032614864 @default.
- W2024349152 cites W2033835817 @default.
- W2024349152 cites W2034623405 @default.
- W2024349152 cites W2034649274 @default.
- W2024349152 cites W2039366720 @default.
- W2024349152 cites W2045322355 @default.
- W2024349152 cites W2054958814 @default.
- W2024349152 cites W2058366995 @default.
- W2024349152 cites W2075317178 @default.
- W2024349152 cites W2077273426 @default.
- W2024349152 cites W2092667863 @default.
- W2024349152 cites W2096223538 @default.
- W2024349152 cites W2102501526 @default.
- W2024349152 cites W2104828162 @default.
- W2024349152 cites W2111567736 @default.
- W2024349152 cites W2116060738 @default.
- W2024349152 cites W2134175299 @default.
- W2024349152 cites W2138122919 @default.
- W2024349152 cites W2143485119 @default.
- W2024349152 cites W2143902924 @default.
- W2024349152 cites W2145957163 @default.
- W2024349152 cites W2152074075 @default.
- W2024349152 cites W2157808629 @default.
- W2024349152 doi "https://doi.org/10.1016/j.lfs.2014.11.010" @default.
- W2024349152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25476834" @default.
- W2024349152 hasPublicationYear "2015" @default.
- W2024349152 type Work @default.
- W2024349152 sameAs 2024349152 @default.
- W2024349152 citedByCount "7" @default.
- W2024349152 countsByYear W20243491522015 @default.
- W2024349152 countsByYear W20243491522017 @default.
- W2024349152 countsByYear W20243491522018 @default.
- W2024349152 countsByYear W20243491522019 @default.
- W2024349152 countsByYear W20243491522021 @default.
- W2024349152 countsByYear W20243491522023 @default.
- W2024349152 crossrefType "journal-article" @default.
- W2024349152 hasAuthorship W2024349152A5026683831 @default.
- W2024349152 hasAuthorship W2024349152A5040590261 @default.
- W2024349152 hasAuthorship W2024349152A5066998394 @default.
- W2024349152 hasConcept C142724271 @default.
- W2024349152 hasConcept C185592680 @default.
- W2024349152 hasConcept C204787440 @default.
- W2024349152 hasConcept C2778004101 @default.
- W2024349152 hasConcept C2781263971 @default.
- W2024349152 hasConcept C2781347565 @default.
- W2024349152 hasConcept C28406088 @default.
- W2024349152 hasConcept C55493867 @default.
- W2024349152 hasConcept C71924100 @default.
- W2024349152 hasConcept C79879829 @default.
- W2024349152 hasConceptScore W2024349152C142724271 @default.
- W2024349152 hasConceptScore W2024349152C185592680 @default.
- W2024349152 hasConceptScore W2024349152C204787440 @default.
- W2024349152 hasConceptScore W2024349152C2778004101 @default.
- W2024349152 hasConceptScore W2024349152C2781263971 @default.
- W2024349152 hasConceptScore W2024349152C2781347565 @default.
- W2024349152 hasConceptScore W2024349152C28406088 @default.
- W2024349152 hasConceptScore W2024349152C55493867 @default.
- W2024349152 hasConceptScore W2024349152C71924100 @default.
- W2024349152 hasConceptScore W2024349152C79879829 @default.
- W2024349152 hasFunder F4320324162 @default.
- W2024349152 hasLocation W20243491521 @default.
- W2024349152 hasOpenAccess W2024349152 @default.
- W2024349152 hasPrimaryLocation W20243491521 @default.
- W2024349152 hasRelatedWork W1514451801 @default.
- W2024349152 hasRelatedWork W1816636001 @default.
- W2024349152 hasRelatedWork W1979534999 @default.
- W2024349152 hasRelatedWork W1984947713 @default.
- W2024349152 hasRelatedWork W2012001430 @default.
- W2024349152 hasRelatedWork W2071562112 @default.
- W2024349152 hasRelatedWork W2110998913 @default.
- W2024349152 hasRelatedWork W2366595807 @default.
- W2024349152 hasRelatedWork W4318357236 @default.
- W2024349152 hasRelatedWork W190756422 @default.
- W2024349152 hasVolume "121" @default.
- W2024349152 isParatext "false" @default.
- W2024349152 isRetracted "false" @default.
- W2024349152 magId "2024349152" @default.
- W2024349152 workType "article" @default.