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• W2024350761 abstract "Introduction. Reduced kidney function, approximated by elevated cystatin C, is associated with diastolic dysfunction, heart failure, and cardiovascular mortality; however, the precise mechanism(s) that account for these relationships remains unclear. Understanding the relationship between cystatin C and subclinical left ventricular (LV) remodeling, across ethnically diverse populations, may help explain the mechanisms underlying the association of kidney dysfunction with heart failure and cardiovascular mortality. Methods. Measures of cystatin C and LV parameters were obtained from the multi-ethnic study of atherosclerosis (MESA) cohort at baseline (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>N</mml:mi><mml:mo>=</mml:mo><mml:mn>4</mml:mn><mml:mo>,</mml:mo><mml:mn>970</mml:mn></mml:math>with complete data on cystatin C and LV parameters). LV parameters; LV end-diastolic (LVEDV) and end-systolic volumes (LVESV), LV mass (LVM), concentricity (LV mass/LV end-diastolic volume), and LV ejection fraction (LVEF) were measured using magnetic resonance imaging. Nested linear models were used to examine the relationship between higher quartiles of cystatin C and LV parameters, with and without adjustment for demographics, height, and weight, and traditional cardiovascular risk factors. Similar analyses were performed stratified by ethnicity and gender. Results. A fully adjusted model demonstrated a linear relationship between higher quartiles of cystatin C and lower LVEDV, (Mean ± SE, 128 ± 0.7, 128 ± 0.7, 126 ± 0.7, 124 ± 0.8 mL;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0001</mml:mn></mml:math>). Associations were also observed between higher quartiles of cystatin C and lower LVESV (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.04</mml:mn></mml:math>) and concentricity (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0001</mml:mn></mml:math>). In contrast, no association was detected between cystatin C and LVM or LVEF. In analyses stratified by race and gender, the patterns of association between cystatin C quartiles and LV parameters were qualitatively similar to the overall association. Conclusion. Cystatin C levels were inversely associated with LVEDV and LVESV with a disproportionate decrease in LVEDV compared to LVM in a multi-ethnic population. This morphometric pattern of concentric left ventricular remodeling, may in part explain the process by which kidney dysfunction leads to diastolic dysfunction, heart failure and cardiovascular mortality." @default.
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• W2024350761 date "2011-01-01" @default.
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• W2024350761 title "Association between Cystatin C and MRI Measures of Left Ventricular Structure and Function: Multi-Ethnic Study of Atherosclerosis" @default.
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• W2024350761 doi "https://doi.org/10.4061/2011/153868" @default.
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