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- W2024351212 abstract "Analogues of brusatol (2) were prepared and examined for their cytotoxic activity by using P-388 murine leukemia cells. The following structure–activity relationships were noted: (i) an enone carbonyl oxygen or an enolic oxygen at C-2 is essential, but an oxygen at C-3 not essential for the activity; (ii) the C-11 β-hydroxyl group is important for the activity; and (iii) the length of the ester alkoxy side chain at C-21 seems to have a slight effect on the activity." @default.
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- W2024351212 date "2006-04-01" @default.
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- W2024351212 title "A structure–activity relationship study of brusatol, an antitumor quassinoid" @default.
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