FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024351332> ?p ?o ?g. }

• W2024351332 endingPage "9766" @default.
• W2024351332 startingPage "9753" @default.
• W2024351332 abstract "Pro-endothelial monocyte-activating polypeptide II (EMAP II), one component of the multi-aminoacyl tRNA synthetase complex, plays multiple roles in physiological and pathological processes of protein translation, signal transduction, immunity, lung development, and tumor growth. Recent studies have determined that pro-EMAP II has an essential role in maintaining axon integrity in central and peripheral neural systems where deletion of the C terminus of pro-EMAP II has been reported in a consanguineous Israeli Bedouin kindred suffering from Pelizaeus-Merzbacher-like disease. We hypothesized that the N terminus of pro-EMAP II has an important role in the regulation of protein-protein interactions. Using a GFP reporter system, we defined a putative leucine zipper in the N terminus of human pro-EMAP II protein (amino acid residues 1-70) that can form specific strip-like punctate structures. Through GFP punctum analysis, we uncovered that the pro-EMAP II C terminus (amino acids 147-312) can repress GFP punctum formation. Pulldown assays confirmed that the binding between the pro-EMAP II N terminus and its C terminus is mediated by a putative leucine zipper. Furthermore, the pro-EMAP II 1-70 amino acid region was identified as the binding partner of arginyl-tRNA synthetase, a polypeptide of the multi-aminoacyl tRNA synthetase complex. We also determined that the punctate GFP pro-EMAP II 1-70 amino acid aggregate colocalizes and binds to the neurofilament light subunit protein that is associated with pathologic neurofilament network disorganization and degeneration of motor neurons. These findings indicate the structure and binding interaction of pro-EMAP II protein and suggest a role of this protein in pathological neurodegenerative diseases." @default.
• W2024351332 created "2016-06-24" @default.
• W2024351332 creator A5006708086 @default.
• W2024351332 creator A5038775225 @default.
• W2024351332 creator A5042603348 @default.
• W2024351332 creator A5047602817 @default.
• W2024351332 creator A5055707568 @default.
• W2024351332 date "2015-04-01" @default.
• W2024351332 modified "2023-10-17" @default.
• W2024351332 title "The N Terminus of Pro-endothelial Monocyte-activating Polypeptide II (EMAP II) Regulates Its Binding with the C Terminus, Arginyl-tRNA Synthetase, and Neurofilament Light Protein" @default.
• W2024351332 cites W1518183262 @default.
• W2024351332 cites W1560197628 @default.
• W2024351332 cites W1579598940 @default.
• W2024351332 cites W1581361507 @default.
• W2024351332 cites W1605519347 @default.
• W2024351332 cites W1967128351 @default.
• W2024351332 cites W1967509044 @default.
• W2024351332 cites W1990412887 @default.
• W2024351332 cites W2001902614 @default.
• W2024351332 cites W2001981640 @default.
• W2024351332 cites W2004955970 @default.
• W2024351332 cites W2008397659 @default.
• W2024351332 cites W2011017551 @default.
• W2024351332 cites W2020114724 @default.
• W2024351332 cites W2021131957 @default.
• W2024351332 cites W2021966775 @default.
• W2024351332 cites W2028469673 @default.
• W2024351332 cites W2029795228 @default.
• W2024351332 cites W2031637933 @default.
• W2024351332 cites W2032393597 @default.
• W2024351332 cites W2042862010 @default.
• W2024351332 cites W2046128871 @default.
• W2024351332 cites W2052988631 @default.
• W2024351332 cites W2054732430 @default.
• W2024351332 cites W2055054335 @default.
• W2024351332 cites W2058469726 @default.
• W2024351332 cites W2066668488 @default.
• W2024351332 cites W2072938487 @default.
• W2024351332 cites W2073341281 @default.
• W2024351332 cites W2078194579 @default.
• W2024351332 cites W2091965214 @default.
• W2024351332 cites W2103893134 @default.
• W2024351332 cites W2120499500 @default.
• W2024351332 cites W2120632564 @default.
• W2024351332 cites W2125131472 @default.
• W2024351332 cites W2125261775 @default.
• W2024351332 cites W2133654662 @default.
• W2024351332 cites W2134394781 @default.
• W2024351332 cites W2154137725 @default.
• W2024351332 cites W2155768339 @default.
• W2024351332 cites W2159907554 @default.
• W2024351332 cites W2161726811 @default.
• W2024351332 cites W4231212639 @default.
• W2024351332 doi "https://doi.org/10.1074/jbc.m114.630533" @default.
• W2024351332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4392274" @default.
• W2024351332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25724651" @default.
• W2024351332 hasPublicationYear "2015" @default.
• W2024351332 type Work @default.
• W2024351332 sameAs 2024351332 @default.
• W2024351332 citedByCount "4" @default.
• W2024351332 countsByYear W20243513322018 @default.
• W2024351332 countsByYear W20243513322019 @default.
• W2024351332 countsByYear W20243513322020 @default.
• W2024351332 crossrefType "journal-article" @default.
• W2024351332 hasAuthorship W2024351332A5006708086 @default.
• W2024351332 hasAuthorship W2024351332A5038775225 @default.
• W2024351332 hasAuthorship W2024351332A5042603348 @default.
• W2024351332 hasAuthorship W2024351332A5047602817 @default.
• W2024351332 hasAuthorship W2024351332A5055707568 @default.
• W2024351332 hasBestOaLocation W20243513321 @default.
• W2024351332 hasConcept C104317684 @default.
• W2024351332 hasConcept C14053116 @default.
• W2024351332 hasConcept C153911025 @default.
• W2024351332 hasConcept C167625842 @default.
• W2024351332 hasConcept C185592680 @default.
• W2024351332 hasConcept C515207424 @default.
• W2024351332 hasConcept C55493867 @default.
• W2024351332 hasConcept C57711820 @default.
• W2024351332 hasConcept C86803240 @default.
• W2024351332 hasConcept C95444343 @default.
• W2024351332 hasConceptScore W2024351332C104317684 @default.
• W2024351332 hasConceptScore W2024351332C14053116 @default.
• W2024351332 hasConceptScore W2024351332C153911025 @default.
• W2024351332 hasConceptScore W2024351332C167625842 @default.
• W2024351332 hasConceptScore W2024351332C185592680 @default.
• W2024351332 hasConceptScore W2024351332C515207424 @default.
• W2024351332 hasConceptScore W2024351332C55493867 @default.
• W2024351332 hasConceptScore W2024351332C57711820 @default.
• W2024351332 hasConceptScore W2024351332C86803240 @default.
• W2024351332 hasConceptScore W2024351332C95444343 @default.
• W2024351332 hasFunder F4320332161 @default.
• W2024351332 hasIssue "15" @default.
• W2024351332 hasLocation W20243513321 @default.
• W2024351332 hasLocation W20243513322 @default.
• W2024351332 hasLocation W20243513323 @default.
• W2024351332 hasLocation W20243513324 @default.
• W2024351332 hasOpenAccess W2024351332 @default.
• W2024351332 hasPrimaryLocation W20243513321 @default.

• next