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- W2024351368 abstract "With 38 lindane analogs in which some of the chlorine atoms are replaced by other substituents, the relationship between structure and insecticidal activity on mosquitos (Culex pipiens pallens) was analyzed by means of physicochemical substituent parameters and regression analysis. A sufficient hydrophobicity as well as a sufficient stability for spontaneous decomposition in vivo appeared to be indispensable to the activity. For analogs satisfying these conditions, the relative insecticidal activity was determined by steric effects of substituents in a manner highly specific to their positions in the molecule. In order to exhibit potent activity, the analogs were assumed to fit a hypothetical cavity wall at the critical site of action with a proper contact at the meso-positions as well as with a suitable engulfment at the dl-positions. Remarkably, the meso-Br analogs are 1.5–2 times more active than lindane. Substituents other than Cl at the dl-positions generally reduce the activity." @default.
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- W2024351368 date "1978-02-01" @default.
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- W2024351368 title "Structure-activity relationship of lindane analogs" @default.
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- W2024351368 doi "https://doi.org/10.1016/0048-3575(78)90090-1" @default.
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