FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024351685> ?p ?o ?g. }

• W2024351685 endingPage "4174" @default.
• W2024351685 startingPage "4167" @default.
• W2024351685 abstract "Trans-activating response region (TAR) DNA-binding protein of 43 kDa (TDP-43) is an RNA-binding protein that is mutated in familial amyotrophic lateral sclerosis (ALS). Disease-linked mutations in TDP-43 increase the tendency of TDP-43 to aggregate, leading to a corresponding increase in formation of stress granules, cytoplasmic protein/RNA complexes that form in response to stress. Although the field has focused on stress granules, TDP-43 also forms other types of RNA granules. For example, TDP-43 is associated with RNA granules that are prevalent throughout the dendritic arbor in neurons. Because aggregation of TDP-43 is also important for the formation of these neuronal RNA granules, we hypothesized that disease-linked mutations might alter granule formation even in the absence of stress. We now report that ALS-linked mutations in TDP-43 (A315T and Q343R) increase the size of neuronal TDP-43 granules in the dendritic arbor of rat hippocampal neurons. The mutations correspondingly reduce the granule density, movement, and mobility of TDP-43 granules. Depolarization of rat hippocampal neurons with KCl stimulates TDP-43 granule migration into dendrites, but A315T and Q343R TDP-43 granules migrate shorter distances and into fewer dendrites than wild-type TDP-43. These findings highlight novel elements of TDP-43 biology that are affected by disease-linked mutations and suggest a neuronally selective mechanism through which TDP-43 mutations might elicit neuronal dysfunction." @default.
• W2024351685 created "2016-06-24" @default.
• W2024351685 creator A5009073175 @default.
• W2024351685 creator A5015449892 @default.
• W2024351685 creator A5024069942 @default.
• W2024351685 creator A5051928845 @default.
• W2024351685 creator A5058278504 @default.
• W2024351685 creator A5062891826 @default.
• W2024351685 creator A5066049259 @default.
• W2024351685 creator A5067665518 @default.
• W2024351685 creator A5071579004 @default.
• W2024351685 creator A5083604223 @default.
• W2024351685 date "2014-03-19" @default.
• W2024351685 modified "2023-10-17" @default.
• W2024351685 title "ALS-Linked Mutations Enlarge TDP-43-Enriched Neuronal RNA Granules in the Dendritic Arbor" @default.
• W2024351685 cites W1965286266 @default.
• W2024351685 cites W1976011146 @default.
• W2024351685 cites W1985175917 @default.
• W2024351685 cites W1989177998 @default.
• W2024351685 cites W1993434836 @default.
• W2024351685 cites W1994285313 @default.
• W2024351685 cites W1998778692 @default.
• W2024351685 cites W2003618511 @default.
• W2024351685 cites W2016332933 @default.
• W2024351685 cites W2020159880 @default.
• W2024351685 cites W2026928801 @default.
• W2024351685 cites W2028611597 @default.
• W2024351685 cites W2032719480 @default.
• W2024351685 cites W2038815755 @default.
• W2024351685 cites W2047569375 @default.
• W2024351685 cites W2060164680 @default.
• W2024351685 cites W2069045437 @default.
• W2024351685 cites W2074795212 @default.
• W2024351685 cites W2075588816 @default.
• W2024351685 cites W2080620346 @default.
• W2024351685 cites W2087786585 @default.
• W2024351685 cites W2099540110 @default.
• W2024351685 cites W2101042581 @default.
• W2024351685 cites W2112538318 @default.
• W2024351685 cites W2114872355 @default.
• W2024351685 cites W2116660354 @default.
• W2024351685 cites W2131321387 @default.
• W2024351685 cites W2131725903 @default.
• W2024351685 cites W2132121416 @default.
• W2024351685 cites W2135457495 @default.
• W2024351685 cites W2141231623 @default.
• W2024351685 cites W2146627025 @default.
• W2024351685 cites W2147802916 @default.
• W2024351685 cites W2148253741 @default.
• W2024351685 cites W2166315184 @default.
• W2024351685 cites W2167874626 @default.
• W2024351685 cites W2169931542 @default.
• W2024351685 doi "https://doi.org/10.1523/jneurosci.2350-13.2014" @default.
• W2024351685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3960463" @default.
• W2024351685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24647938" @default.
• W2024351685 hasPublicationYear "2014" @default.
• W2024351685 type Work @default.
• W2024351685 sameAs 2024351685 @default.
• W2024351685 citedByCount "97" @default.
• W2024351685 countsByYear W20243516852014 @default.
• W2024351685 countsByYear W20243516852015 @default.
• W2024351685 countsByYear W20243516852016 @default.
• W2024351685 countsByYear W20243516852017 @default.
• W2024351685 countsByYear W20243516852018 @default.
• W2024351685 countsByYear W20243516852019 @default.
• W2024351685 countsByYear W20243516852020 @default.
• W2024351685 countsByYear W20243516852021 @default.
• W2024351685 countsByYear W20243516852022 @default.
• W2024351685 countsByYear W20243516852023 @default.
• W2024351685 crossrefType "journal-article" @default.
• W2024351685 hasAuthorship W2024351685A5009073175 @default.
• W2024351685 hasAuthorship W2024351685A5015449892 @default.
• W2024351685 hasAuthorship W2024351685A5024069942 @default.
• W2024351685 hasAuthorship W2024351685A5051928845 @default.
• W2024351685 hasAuthorship W2024351685A5058278504 @default.
• W2024351685 hasAuthorship W2024351685A5062891826 @default.
• W2024351685 hasAuthorship W2024351685A5066049259 @default.
• W2024351685 hasAuthorship W2024351685A5067665518 @default.
• W2024351685 hasAuthorship W2024351685A5071579004 @default.
• W2024351685 hasAuthorship W2024351685A5083604223 @default.
• W2024351685 hasBestOaLocation W20243516851 @default.
• W2024351685 hasConcept C104317684 @default.
• W2024351685 hasConcept C105580179 @default.
• W2024351685 hasConcept C117838200 @default.
• W2024351685 hasConcept C126322002 @default.
• W2024351685 hasConcept C136238340 @default.
• W2024351685 hasConcept C148762608 @default.
• W2024351685 hasConcept C149364088 @default.
• W2024351685 hasConcept C151730666 @default.
• W2024351685 hasConcept C153911025 @default.
• W2024351685 hasConcept C169760540 @default.
• W2024351685 hasConcept C185592680 @default.
• W2024351685 hasConcept C2779134260 @default.
• W2024351685 hasConcept C2780596555 @default.
• W2024351685 hasConcept C41282012 @default.
• W2024351685 hasConcept C49760210 @default.
• W2024351685 hasConcept C54355233 @default.
• W2024351685 hasConcept C67705224 @default.

• next