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• W2024351690 startingPage "1160" @default.
• W2024351690 abstract "This essay presents a scenario of the origin of life that is based on analysis of biological architecture and mechanical design at the microstructural level. My thesis is that the same architectural and energetic constraints that shape cells today also guided the evolution of the first cells and that the molecular scaffolds that support solid-phase biochemistry in modern cells represent living microfossils of past life forms. This concept emerged from the discovery that cells mechanically stabilize themselves using tensegrity architecture and that these same building rules guide hierarchical self-assembly at all size scales (Sci. Amer 278:48-57;1998). When combined with other fundamental design principles (e.g., energy minimization, topological constraints, structural hierarchies, autocatalytic sets, solid-state biochemistry), tensegrity provides a physical basis to explain how atomic and molecular elements progressively self-assembled to create hierarchical structures with increasingly complex functions, including living cells that can self-reproduce." @default.
• W2024351690 created "2016-06-24" @default.
• W2024351690 creator A5023544944 @default.
• W2024351690 date "2000-11-10" @default.
• W2024351690 modified "2023-09-25" @default.
• W2024351690 title "The origin of cellular life" @default.
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• W2024351690 doi "https://doi.org/10.1002/1521-1878(200012)22:12<1160::aid-bies14>3.0.co;2-5" @default.
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